{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:19:42Z","timestamp":1773307182478,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["990017"],"award-info":[{"award-number":["990017"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The SARS\u2010CoV\u20102 COVID\u201019 pandemic has emerged as an unprecedented emergency state in healthcare system and global challenge. In recent decade, the function of exogenous H<jats:sub>2<\/jats:sub>S in the treatment of respiratory diseases has been investigated using H<jats:sub>2<\/jats:sub>S\u2010donor agents. <jats:italic>Ferula foetida<\/jats:italic> is a medicinal plant that is traditionally used in respiratory diseases including asthma and viral respiratory diseases. The oleo\u2010gum of this plant is a rich source of several organic sulfides including thiophenes, disulfides and polysulfide derivatives, which can act as H<jats:sub>2<\/jats:sub>S\u2010donor agents. The purpose of this study was to investigate the efficacy of Covexir\u00ae (<jats:italic>F. foetida<\/jats:italic> oleo\u2010gum) treatment as a rich source of H<jats:sub>2<\/jats:sub>S\u2010donor compounds in clinical presentations of patients with COVID\u201019. The efficacy of Covexir\u00ae was evaluated in a randomized, double\u2010blind, placebo\u2010controlled trial in outpatients with COVID\u201019. Covexir\u00ae could significantly inhibit cough when compared to the placebo group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.01 and <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009001, respectively). Moreover, there was a significant difference (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009001) between the two groups in dyspnea symptom at follow\u2010up interval of 7\u00a0day after receiving Covexir\u00ae. Furthermore, on days 3 and 7, statistically significant differences were observed in myalgia, anorexia, anosmia, and sense of taste severity between two groups. Our findings revealed that Covexir\u00ae was very safe in the treatment of COVID\u201019 patients with mild to moderate symptoms and it can be recommended to improve clinical presentations of patients with COVID\u201019 such as cough, shortness of breath, myalgia, anorexia, anosmia, and sense of taste.<\/jats:p>","DOI":"10.1002\/ptr.7567","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:09:02Z","timestamp":1658966942000},"page":"4504-4515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of Covexir\u00ae (<i>Ferula foetida<\/i> oleo\u2010gum) treatment in symptomatic improvement of patients with mild to moderate <scp>COVID<\/scp>\u201019: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-6123","authenticated-orcid":false,"given":"Maede","family":"Hasanpour","sequence":"first","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Safari","sequence":"additional","affiliation":[{"name":"Hasheminezhad Hospital Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Hooshang","family":"Mohammadpour","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milad","family":"Iranshahy","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Javad","family":"Dehghan Nayyeri","sequence":"additional","affiliation":[{"name":"Hasheminezhad Hospital Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faegheh","family":"Farhadi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Herbal and Traditional Medicines Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahareh","family":"Emami","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-5750","authenticated-orcid":false,"given":"Mehrdad","family":"Iranshahi","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0114TR"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705710104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2016.1122590"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15230"},{"key":"e_1_2_9_6_1","unstructured":"Coronavirus Outbreak. (2020). Retrieved fromhttps:\/\/www.worldometers.info\/coronavirus\/"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"7","article-title":"Effectiveness of Sulphur spa therapy with politzer in the treatment of rhinogenic deafness","volume":"26","author":"Costantino M.","year":"2006","journal-title":"Acta Otorhinolaryngologica Italica"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2021.100141"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/np010541h"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2021.100755"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33101-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1430358"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8060"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2016.1235693"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.05.009"},{"key":"e_1_2_9_16_1","first-page":"49","volume-title":"PDR for herbal medicines","author":"Healthcare T.","year":"2004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(74)90884-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-020-05762-w"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S100534"},{"issue":"2","key":"e_1_2_9_20_1","first-page":"775","article-title":"Ferula foetida \u201cHing\u201d: A review","volume":"3","author":"Kareparamban J.","year":"2012","journal-title":"Research Journal of Pharmaceutical, Biological and Chemical Sciences"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-013-0535-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321871111"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2021.102769"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3379"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b01962"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10010079"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6159"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2508"},{"issue":"4","key":"e_1_2_9_29_1","first-page":"23","article-title":"COVID\u201019: An applied intervention through ayurveda","volume":"8","author":"Namburi U. S.","year":"2020","journal-title":"International Journal of Ayurveda and Pharma Research"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.04.001"},{"key":"e_1_2_9_31_1","volume-title":"WHO director\u2010General's opening remarks at the media briefing on COVID\u201019\u201011 March 2020","author":"Organization W. H.","year":"2020"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1560638"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12128"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4723416"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001562"},{"key":"e_1_2_9_36_1","first-page":"25","article-title":"Chemical composition and properties of essential oil of Ferula foetida (Bunge) regel growing on Mangyshlak peninsula","volume":"4","author":"Sagyndykova M.","year":"2019","journal-title":"\u0421\u0435\u0440\u0438\u044f: \u0425\u0438\u043c\u0438\u044f"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.52586\/4924"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1277782"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2467"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.685734"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.18474\/0749-8004-20.2.225"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4433"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30185-9"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/v2081803"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00187.2020"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6270fje"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190514"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.7567","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T08:22:36Z","timestamp":1692260556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/ptr.7567"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7567","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,27]]},"assertion":[{"value":"2021-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}