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Consequently, this study aimed to examine the effects of GS supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults. Eligible randomized controlled trials (RCT), published up to November 2021, were identified through PubMed, Scopus, and ISI Web of Science databases. Six studies were included and analyzed using a random\u2010effects model to calculate weighted mean differences (WMDs) with 95% confidence intervals (CI). All studies were conducted in adults that used a GC supplement (&gt;1\u2009week) and assessed our selected cardiovascular risk factors. Outcomes revealed that GS supplementation significantly decreased triglyceride (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001), total cholesterol (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001), low\u2010density lipoprotein (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001), fasting blood sugar (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001), and diastolic blood pressure (<jats:italic>p<\/jats:italic>\u00a0=\u2009.003). Some limitations, including notable heterogeneity, low quality of studies, and lack of diversity among research participants, should be considered when interpreting our results. Our outcomes suggest that GS supplementation may improve cardiovascular risk factors. Future large\u2010high\u2010quality RCTs with longer duration and various populations are needed to firmly establish the clinical efficacy of the plant.<\/jats:p>","DOI":"10.1002\/ptr.7585","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T19:20:05Z","timestamp":1672341605000},"page":"949-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"37","author":[{"given":"Mohammad","family":"Zamani","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutritional sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-6110","authenticated-orcid":false,"given":"Damoon","family":"Ashtary\u2010Larky","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Nosratabadi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology University of Isfahan  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-8850","authenticated-orcid":false,"given":"Alexei","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Health and Human Performance Marymount University  Arlington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahdi","family":"Rafiei","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit \u0301e de Montr \u0301eal (CRCHUM)  Montr\u00e9al Canada"},{"name":"School of Kinesiology and Physical Activity Sciences, Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba Mahdavi","family":"Asiabar","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, Sanandaj Branch Islamice Azad University  Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardis","family":"Khalili","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Science and Research Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-4711","authenticated-orcid":false,"given":"Omid","family":"Asbaghi","sequence":"additional","affiliation":[{"name":"Cancer Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-8367","authenticated-orcid":false,"given":"Sayed Hosein","family":"Davoodi","sequence":"additional","affiliation":[{"name":"Cancer Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3125"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-008-9079-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1890689"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"The effect of exercise training on serum concentrations of chemerin in patients with metabolic diseases: A systematic review and meta\u2010analysis","author":"Ashtary\u2010Larky D.","year":"2021","journal-title":"Archives of Physiology and Biochemistry"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","unstructured":"Balasubramaniam K. 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