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Berberine (BBR) is a monomer compound with various biological functions. And some studies have confirmed that BBR plays an important role in alleviating cardiomyocyte injury after MI. However, the specific mechanism is unclear. In this study, we induced a model of MI by ligation of the left anterior descending coronary artery and we surprisingly found that BBR significantly improved ventricular remodeling, with a minor inflammatory and oxidative stress injury, and stronger angiogenesis. Moreover, BBR inhibited the secretion of Wnt5a\/\u03b2\u2010catenin pathway in macrophages after MI, thus promoting the differentiation of macrophages into M2 type. In summary, BBR effectively improved cardiac function of mice after MI, and the potential protective mechanism was associated with the regulation of inflammatory responses and the inhibition of macrophage Wnt5a\/\u03b2\u2010catenin pathway in the infarcted heart tissues. Importantly, these findings supported BBR as an effective cardioprotective drug after MI.<\/jats:p>","DOI":"10.1002\/ptr.7592","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T11:39:06Z","timestamp":1665488346000},"page":"50-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Berberine plays a cardioprotective role by inhibiting macrophage Wnt5a\/\u03b2\u2010catenin pathway in the myocardium of mice after myocardial infarction"],"prefix":"10.1002","volume":"37","author":[{"given":"Chun\u2010xia","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Department of Cardiology Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan Hubei 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