{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:35:26Z","timestamp":1790951726431,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874404"],"award-info":[{"award-number":["81874404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study explored the therapeutic effect of \u03b1\u2010asarone on chronic sciatica. Thirty\u2010two Sprague\u2013Dawley (SD) rats were divided into four groups: the sham group, chronic constriction injury (CCI) group, pregabalin group, and \u03b1\u2010asarone group. Hot hyperalgesia was induced after the CCI operation, and \u03b1\u2010asarone was found to relieve chronic neuralgia. Furthermore, \u03b1\u2010asarone reduced IL1\u03b2, IL6, TNF\u2010\u03b1, CRP, and LPS levels and increased IL10 levels in serum. \u03b1\u2010Asarone decreased the protein levels of TRPA1, TRPM8, and TRPV1\u20104 and the mRNA levels of TRPA1, TRPM8, TRPV1\u20104, IL1\u03b2, and TNF\u2010\u03b1 in dorsal root ganglion neurons. In the sciatic nerve, \u03b1\u2010asarone treatment reduced the number of inflammatory cells and promoted the proliferation of Schwann cells, favouring recovery of the nerve structure. In cellular experiments, LPS induced Schwann cell apoptosis via TLR4\/p38MAPK signalling; \u03b1\u2010asarone attenuated LPS\u2010induced Schwann cell apoptosis by decreasing TLR4, p\u2010p38MAPK, cleaved\u2010caspase3, and cleaved\u2010caspase7 levels and increasing Bcl\u20102 and Bcl\u2010xl expression. Overall, these findings suggest that \u03b1\u2010asarone relieves chronic sciatica by decreasing the levels of inflammatory factors, inhibiting peripheral sensitization, and favouring the repair of damaged nerves.<\/jats:p>","DOI":"10.1002\/ptr.7603","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:44:12Z","timestamp":1662597852000},"page":"151-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<scp>\u03b1\u2010Asarone<\/scp> attenuates chronic sciatica by inhibiting peripheral sensitization and promoting neural repair"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9134-6573","authenticated-orcid":false,"given":"Di","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Jing","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenni","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yachun","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiquan","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Integrated Hospital of Traditional Chinese Medicine Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.10.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.4.JNS121189"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7396"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1lc00876e"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.322446"},{"key":"e_1_2_11_7_1","volume-title":"StatPearls","author":"Davis D.","year":"2022"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2017.02.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010342"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-022-00205-y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154363"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.12.FOCUS16474"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/Ane.0000000000002792"},{"key":"e_1_2_11_14_1","unstructured":"Institute of Laboratory Animal Resources (U.S.).Institute of Laboratory Animal Resources (U.S.). Committee on Care and Use of Laboratory Animals. Guide for the care and use of laboratory animals. In NIH publication (pp. volumes). Bethesda Md.: U.S. Dept. of Health and Human Services Public Health Service."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X690198"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2007.01.008"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-016-0288-x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph9040072"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.10.029"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.05.023"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.716684"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.12.026"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7472"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-022-00251-z"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2021.08.006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10676"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2545806"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.7603","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T20:06:56Z","timestamp":1692389216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/ptr.7603"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7603","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]},"assertion":[{"value":"2022-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}