{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:50:19Z","timestamp":1788382219691,"version":"build-2803163510"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073851"],"award-info":[{"award-number":["82073851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isopsoralen (IPRN), which comes from the fruit of <jats:italic>Psoralea corylifolia<\/jats:italic>, has been identified as a kind of phytoestrogen and has been proven to be effective for the treatment of osteoporosis (OP). However, the mechanisms underlying IPRN's anti\u2010OP effects, especially the anti\u2010postmenopausal osteoporosis (PMOP) effects, remain indistinct. Thus, this study aimed to investigate the effects and mechanisms of IPRN's anti\u2010PMOP activity. In this study, the bioinformatics results predicted that IPRN could resist PMOP by targeting EGFR, AKT1, SRC, CCND1, ESR1 (ER\u2010\u03b1), AR, PGR, BRCA1, PTGS2, and IGF1R. An ovariectomized (OVX) mice model and a H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced bone marrow mesenchyml stem cells (BMSCs) model confirmed that IPRN could inhibit the bone loss induced by OVX in mice and promote the osteogenic differentiation in H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced BMSCs by inhibiting oxidative stress and apoptosis. Moreover, IPRN could significantly produce the above effects by upregulating ESR1. IPRN might be a therapeutic agent for PMOP by acting as an estrogen replacement agent and a natural antioxidant.<\/jats:p>","DOI":"10.1002\/ptr.7609","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T02:50:25Z","timestamp":1663642225000},"page":"231-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Anti\u2010Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics\u2010integrated experimental study"],"prefix":"10.1002","volume":"37","author":[{"given":"Hao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, College of Pharmacy Dalian Medical University  Dalian China"},{"name":"Academy of Integrative Medicine Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, 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