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We recently demonstrated the antiadipogenic efficacy of lutein using a 3 T3\u2010L1 cell culture model. This study aimed to examine the antiobesity efficacy of lutein on high\u2010fat (60% kcal fat) diet\u2010induced C57BL\/6J obese mice model. Lutein (300 and 500\u2009\u03bcM), Orlistat (30\u2009mg\/kg body weight \u2010 positive control), and its combination (orlistat, 15\u2009mg\/kg body weight+lutein, 300\u2009\u03bcM) were administered in high\u2010fat diet (HFD)\u2010fed mice every other day for 24\u2009weeks. The effect on serum and hepatic lipid parameters was estimated using biochemical assay kits. The adipose tissue expression of adipocyte differentiation markers at gene and protein levels was analyzed by RT\u2010PCR and western blotting, respectively. The results showed that lutein administration and drug significantly reduced epididymal and abdominal adipose tissue weights. Further, lutein reduced the serum cholesterol and LDL\u2010C concentration compared to the HFD group. The HFD\u2010induced elevation in the hepatic triglycerides and cholesterol levels were significantly blocked by lutein and its combination with the drug. Similarly, lutein and its drug combination efficiently lowered the HFD\u2010mediated elevated blood glucose levels. Lutein downregulated the expression of CEBP\u2010\u03b1, PPAR\u2010\u03b3, and FAS in the epididymal adipose tissue. Thus, supplementation of lutein may control diet\u2010induced obesity and associated complications in the human population.<\/jats:p>","DOI":"10.1002\/ptr.7615","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T05:59:10Z","timestamp":1662789550000},"page":"329-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Lutein ameliorates high\u2010fat diet\u2010induced obesity, fatty liver, and glucose intolerance in <scp>C57BL<\/scp>\/<scp>6J<\/scp> mice"],"prefix":"10.1002","volume":"37","author":[{"given":"Sowmya Shree","family":"Gopal","sequence":"first","affiliation":[{"name":"Department of Molecular Nutrition CSIR\u2010Central Food Technological Research Institute (CFTRI)  Mysuru India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinde 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