{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:38:53Z","timestamp":1768253933660,"version":"3.49.0"},"reference-count":68,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Almond intake may be correlated with improvements in several cardiometabolic parameters, but its effects are controversial in the published literature, and it needs to be comprehensively summarized. We conducted a systematic search in several international electronic databases, including MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> until April 2021 to identify randomized controlled trials that examined the effects of almond consumption on cardiometabolic risk factors, inflammatory markers, and liver enzymes. Data were pooled using the random\u2010effects model method and presented as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Twenty\u2010six eligible trials were analyzed (<jats:italic>n<\/jats:italic>\u00a0=\u00a01750 participants). Almond intake significantly decreased diastolic blood pressure, total cholesterol, triglyceride, low\u2010density lipoprotein (LDL), non\u2010high\u2010density lipoprotein (HDL), and very LDL (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). The effects of almond intake on systolic blood pressure, fasting blood glucose, insulin, hemoglobin A1c, homeostatic model assessment of insulin resistance, C\u2010peptide, alanine aminotransferase, aspartate aminotransferase, gamma\u2010glutamyl transferase, C\u2010reactive protein (CRP), hs\u2010CRP (high sensitivity C\u2010reactive protein), interleukin 6, tumor necrosis factor\u2010\u03b1, ICAM (Intercellular Adhesion Molecule), VCAM (Vascular Cell Adhesion Molecule), homocysteine, HDL, ox\u2010LDL, ApoA1, ApoB, and lipoprotien\u2010a were not statistically significant (<jats:italic>p<\/jats:italic>\u00a0&gt;\u2009.05). The current body of evidence supports the ingestion of almonds for their beneficial lipid\u2010lowering and antihypertensive effects. However, the effects of almonds on antiinflammatory markers, glycemic control, and hepatic enzymes should be further evaluated via performing more extensive randomized trials.<\/jats:p>","DOI":"10.1002\/ptr.7622","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T10:28:36Z","timestamp":1667557716000},"page":"4325-4344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"36","author":[{"given":"Mojgan","family":"Morvaridzadeh","sequence":"first","affiliation":[{"name":"Songhor Healthcare Center Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Qorbani","sequence":"additional","affiliation":[{"name":"Non\u2010communicable Diseases Research Center Alborz University of Medical Sciences  Karaj Iran"},{"name":"Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Shokati Eshkiki","sequence":"additional","affiliation":[{"name":"Alimentary Tract Research Center, Clinical Science Reseaech Institute Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Dulce","family":"Est\u00eav\u00e3o","sequence":"additional","affiliation":[{"name":"Escola Superior de Sa\u00fade Universidade do Algarve  Faro Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar","family":"Mohammadi Ganjaroudi","sequence":"additional","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Toupchian","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Public Health, School of Health North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2638-7448","authenticated-orcid":false,"given":"Shima","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Public Health, School of Health North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-454X","authenticated-orcid":false,"given":"Ana Beatriz","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Clinical Research Center Fundaci\u00f3n Valle del Lili  Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-2181","authenticated-orcid":false,"given":"Ahmed","family":"Abu\u2010Zaid","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Graduate Health Sciences University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua R.","family":"Zadro","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-0185","authenticated-orcid":false,"given":"Javad","family":"Heshmati","sequence":"additional","affiliation":[{"name":"Songhor Healthcare Center Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Ziaei","sequence":"additional","affiliation":[{"name":"Anesthesiologist, ICU Department, Emam Reza Hospital Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.23628"},{"issue":"5","key":"e_1_2_8_3_1","first-page":"457","article-title":"The effect of almonds on anthropometric measurements and lipid profile in overweight and obese females in a weight reduction program: A randomized controlled clinical trial","volume":"19","author":"Abazarfard Z.","year":"2014","journal-title":"Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114514003729"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030672"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.07.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000993"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/BJN20061864"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095442241100014X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2018.12.088"},{"issue":"1","key":"e_1_2_8_11_1","article-title":"Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes: A randomized, crossover, controlled feeding trial","volume":"14","author":"Chen C. 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