{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:55:33Z","timestamp":1792518933882,"version":"4.5.0"},"reference-count":245,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DBT\u2010BUILDER"],"award-info":[{"award-number":["DBT\u2010BUILDER"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Piper longum<\/jats:italic> (family Piperaceae), commonly known as \u201clong\u2010pepper\u201d or \u201cPippali\u201d grows as a perennial shrub or as an herbaceous vine. It is native to the Indo\u2010Malaya region and widely distributed in the tropical and subtropical world including the Indian subcontinent, Sri Lanka, Middle\u2010East, and America. The fruits are mostly used as culinary spice and preservatives and are also a potent remedy in various traditional medicinal systems against bronchitis, cough, cold, snakebite, and scorpion\u2010sting and are also used as a contraceptive. Various bioactive\u2010phytochemicals including alkaloids, flavonoids, esters, and steroids were identified from the plant extracts and essential oils from the roots and fruits were reported as antimicrobial, antiparasitic, anthelminthic, mosquito\u2010larvicidal, antiinflammatory, analgesic, antioxidant, anticancer, neuro\u2010pharmacological, antihyperglycaemic, hepato\u2010protective, antihyperlipidaemic, antiangiogenic, immunomodulatory, antiarthritic, antiulcer, antiasthmatic, cardioprotective, and anti\u2010snake\u2010venom agents. Many of its pharmacological properties were attributed to its antioxidative and antiinflammatory effects and its ability to modulate a number of signalling pathways and enzymes. This review comprehensively encompasses information on habit, distribution, ethnobotany, phytochemistry, and pharmacology of <jats:italic>P. longum<\/jats:italic> in relation to its medicinal importance and health benefits to validate the traditional claims supported by specific scientific experiments. In addition, it also discusses the safety and toxicity studies, application of green synthesis and nanotechnology as well as clinical trials performed with the plant also elucidating research gaps and future perspectives of its multifaceted uses.<\/jats:p>","DOI":"10.1002\/ptr.7649","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T16:01:27Z","timestamp":1666108887000},"page":"4425-4476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["<i>Piper longum<\/i> L.: A comprehensive review on traditional uses, phytochemistry, pharmacology, and health\u2010promoting activities"],"prefix":"10.1002","volume":"36","author":[{"given":"Protha","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Life Sciences Presidency University  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimosa","family":"Ghorai","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Presidency University  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulika","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Botany DDU Gorakhpur University  Gorakhpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abilash Valsala","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Bio Sciences and Technology Vellore Institute of Technology (VIT)  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debleena","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Botany Lady Brabourne College  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit Bhagwan","family":"Mane","sequence":"additional","affiliation":[{"name":"Department of Zoology Dr. Patangrao Kadam Mahavidhyalaya  Sangli India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Mundhra","sequence":"additional","affiliation":[{"name":"Department of Botany Rishi Bankim Chandra College  Naihati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neela","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Botany Rishi Bankim Chandra College  Naihati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas Moreshwar","family":"Mohture","sequence":"additional","affiliation":[{"name":"Department of Botany Rashtrapita Mahatma Gandhi Arts and Science College  Nagbhid India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Tukaram","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Botany SNJB's KKHA Arts SMGL Commerce and SPHJ Science College Chandwad (Nashik) Maharashtra, Affiliated to Savitribai Phule Pune University  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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