{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:19:28Z","timestamp":1790363968596,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030114"],"award-info":[{"award-number":["82030114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074072"],"award-info":[{"award-number":["82074072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gastric cancer (GC) is a malignancy with high morbidity and mortality. Chinese dragon's blood is a traditional Chinese medicine derived from the red resin of\n                    <jats:italic>Dracaena cochinchinensis<\/jats:italic>\n                    (Lour.) S. C. Chen. However, the antigastric cancer effect of Chinese dragon's blood has not yet been reported. Herein, we demonstrated that Chinese dragon's blood ethyl acetate extract (CDBEE) suppressed the proliferative and metastatic potential of human gastric cancer MGC\u2010803 and HGC\u201027 cells. CDBEE suppressed epithelial\u2013mesenchymal transition in MGC\u2010803 and HGC\u201027 cells. Moreover, CDBEE induced apoptotic and autophagic cell death in MGC\u2010803 and HGC\u201027 cells. The cytotoxicity of CDBEE in human gastric epithelial GES\u20101 cells was dramatically weaker than that in human gastric cancer cells. Mechanistically, the activation of the mitogen\u2010activated protein kinase (MAPK) signalling pathway was involved in the growth inhibition of MGC\u2010803 and HGC\u201027 cells by CDBEE. Additionally, CDBEE\u2010induced autophagic cell death was mediated by downregulation of the mammalian target of rapamycin (mTOR)\u2010Beclin1 signalling cascade and upregulation of the ATG3\/ATG7\u2010LC3 signalling cascade. Importantly, CDBEE exhibited potent anti\u2010GC efficacy in vivo without obvious toxicity or side effects. Therefore, CDBEE may be a promising candidate drug for the treatment of gastric cancer, especially for GC patients with aberrant MAPK signalling or mTOR signalling.\n                  <\/jats:p>","DOI":"10.1002\/ptr.7652","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T03:30:37Z","timestamp":1665977437000},"page":"689-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chinese dragon's blood ethyl acetate extract suppresses gastric cancer progression through induction of apoptosis and autophagy mediated by activation of\n                    <scp>MAPK<\/scp>\n                    and downregulation of the\n                    <scp>mTOR\u2010Beclin1<\/scp>\n                    signalling cascade"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-5339","authenticated-orcid":false,"given":"Lishan","family":"Ouyang","sequence":"first","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Chen","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoran","family":"Pang","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"},{"name":"Innovation Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Wei","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Xie","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing 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