{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:01:28Z","timestamp":1793390488615,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012249","name":"Jiangxi University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["1141900603"],"award-info":[{"award-number":["1141900603"]}],"id":[{"id":"10.13039\/501100012249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20181BAB205082"],"award-info":[{"award-number":["20181BAB205082"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20192BAB215050"],"award-info":[{"award-number":["20192BAB215050"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20192ACB20015"],"award-info":[{"award-number":["20192ACB20015"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060838"],"award-info":[{"award-number":["82060838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060799"],"award-info":[{"award-number":["82060799"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803988"],"award-info":[{"award-number":["81803988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860792"],"award-info":[{"award-number":["81860792"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Curcumin (Cur) is a natural active phenolic compound extracted from the root of\n                    <jats:italic>Curcuma Longa L.<\/jats:italic>\n                    It has anti\u2010inflammatory, anti\u2010tumor and other pharmacological activities, and is commonly used to treat ulcerative colitis (UC). However, it is not clear whether curcumin regulates the function and differentiation of Breg cells to treat UC. In this study, mice with chronic colitis were induced by dextran sulfate sodium (DSS), and treated with curcumin for 12\u2009days. Curcumin effectively improved the body weight, colonic weight, colonic length, decreased colonic weight index and pathological injury score under colonoscopy in mice with chronic colitis, and significantly inhibited the production of IL\u20101\u03b2, IL\u20106, IL\u201033, CCL\u20102, IFN\u2010\u03b3, TNF\u2010\u03b1, and promoted the secretion of IL\u20104, IL\u201010, IL\u201013 and IgA. Importantly, curcumin markedly upregulated CD3\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD19\n                    <jats:sup>+<\/jats:sup>\n                    CD1d\n                    <jats:sup>+<\/jats:sup>\n                    , CD3\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD19\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    , CD3\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD19\n                    <jats:sup>+<\/jats:sup>\n                    Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Breg cells level and significantly down\u2010regulated CD3\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD19\n                    <jats:sup>+<\/jats:sup>\n                    PD\u2010L1\n                    <jats:sup>+<\/jats:sup>\n                    , CD3\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD19\n                    <jats:sup>+<\/jats:sup>\n                    tim\u20101\n                    <jats:sup>+<\/jats:sup>\n                    , CD3\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD19\n                    <jats:sup>+<\/jats:sup>\n                    CD27\n                    <jats:sup>+<\/jats:sup>\n                    Breg cells level. In addition, our results also showed that curcumin observably inhibited TLR2, TLR4, TLR5, MyD88, IRAK4, p\u2010IRAK4, NF\u2010\u03baB P65, IRAK1, TRAF6, TAB1, TAB2, TAK1, MKK3, MKK6, p38MAPK, p\u2010p38MAPK and CREB expression in TLR\/MyD88 signaling pathway. These results suggest that curcumin can regulate the differentiation and function of Breg cell to alleviate DSS\u2010induced colitis, which may be realized by inhibiting TLR\/MyD88 pathway.\n                  <\/jats:p>","DOI":"10.1002\/ptr.7656","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T06:59:24Z","timestamp":1664953164000},"page":"731-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effect of curcumin on regulatory B cells in chronic colitis mice involving\n                    <scp>TLR<\/scp>\n                    \/\n                    <scp>MyD88<\/scp>\n                    signaling pathway"],"prefix":"10.1002","volume":"37","author":[{"given":"Jie","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Postgraduate Jiangxi University of Traditional Chinese Medicine  Nanchang Jiangxi Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Postgraduate Jiangxi University of Traditional Chinese Medicine  Nanchang Jiangxi Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-8639","authenticated-orcid":false,"given":"Youbao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Postgraduate Jiangxi University of Traditional Chinese Medicine  Nanchang Jiangxi Province People's Republic of China"},{"name":"Laboratory Animal Research Center for Science and Technology Jiangxi University of Traditional Chinese Medicine  Nanchang Jiangxi Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Postgraduate Jiangxi University of Traditional Chinese Medicine  Nanchang Jiangxi Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengping","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Postgraduate Jiangxi University of Traditional Chinese Medicine  Nanchang Jiangxi Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bugao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Formula\u2010Pattern Research Center, Jiangxi University of Traditional Chinese Medicine  Nanchang Jiangxi Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jiangxi University of Traditional Chinese Medicine  Nanchang Jiangxi Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-2811","authenticated-orcid":false,"given":"Duanyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Formula\u2010Pattern Research Center, Jiangxi University of Traditional Chinese Medicine  Nanchang Jiangxi Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-020-00451-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.156018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-017-0469-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12594"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i13.1398"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00728.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46274"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.7868"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00544-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005407"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9430763"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112230"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00835"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.09.065"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-021-02374-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3766"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15054"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1487396"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl18072"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6997"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213744"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2012.04.322"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4763"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3665"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000811"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.03.008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00589"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174742"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.48"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci85113"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93820"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxv026"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(02)00274-1"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2019.100011"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2VMA0515-229RR"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00975"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11090943"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01358-y"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1615\/critrevimmunol.v30.i1.10"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09884-6"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.24"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.005"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.08.026"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033628"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6581"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13603-6"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2019.08.012"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-789578"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00330"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00442-2"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005427"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.01.008"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7404"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03161-6"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3784671"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.017"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.022"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801068"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11501"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003860"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02241"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.05.033"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1384521"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.7656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T05:28:09Z","timestamp":1692336489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,5]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/ptr.7656"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7656","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,5]]},"assertion":[{"value":"2022-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}