{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:06:38Z","timestamp":1790381198192,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760657"],"award-info":[{"award-number":["81760657"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Citrus peel has long been used in traditional medicine in Asia to treat common cold, dyspepsia, cough, and phlegm. Narirutin\u2013a flavanone\u20107\u2010O\u2010glycoside\u2013is the major flavonoid in citrus peel, and has anti\u2010oxidative, anti\u2010allergic, and anti\u2010inflammatory activities. However, the anti\u2010inflammatory mechanism of narirutin has not been fully elucidated. This study is aimed to investigate the effects of narirutin on the Nod\u2010like receptor protein 3 (NLRP3)\u2010mediated inflammatory response in vitro and in vivo, and determine the underlying mechanism. THP\u20101 differentiated macrophages and bone marrow\u2010derived macrophages (BMDMs) were used for in vitro experiments, while dextran sulfate sodium (DSS)\u2010induced colitis and alum\u2010induced peritonitis mouse models were constructed to test inflammation in vivo. Narirutin suppressed secretion of interleukin (IL)\u20101\u03b2 and pyroptosis in lipopolysaccharide (LPS)\/ATP\u2010stimulated macrophages. Narirutin decreased the expression of NLRP3 and IL\u20101\u03b2 in the LPS\u2010priming step through inhibition of NF\u2010\u03baB, MAPK and PI3K \/AKT signaling pathways. Narirutin inhibited NLRP3\u2013ASC interaction to suppress NLRP3 inflammasome assembly. Furthermore, oral administration of narirutin (300\u2009mg\/kg) alleviated inflammation symptoms in mice with peritonitis and colitis. These results suggest that narirutin exerts its anti\u2010inflammatory activity by suppressing NLRP3 inflammasome activation via inhibition of the NLRP3 inflammasome priming processes and NLRP3\u2013ASC interaction in macrophages.<\/jats:p>","DOI":"10.1002\/ptr.7686","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T02:37:05Z","timestamp":1675823825000},"page":"1293-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Narirutin exerts anti\u2010inflammatory activity by inhibiting\n                    <scp>NLRP3<\/scp>\n                    inflammasome activation in macrophages"],"prefix":"10.1002","volume":"37","author":[{"given":"Myong Hak","family":"Ri","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy Yanbian University  Yanji 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of Pharmacy Yanbian University  Yanji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy Yanbian University  Yanji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy Yanbian University  Yanji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy Yanbian University  Yanji 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