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This study aimed to evaluate the efficacy of frankincense\u2010based herbal product (FHP) in urinary incontinence compared with placebo and solifenacin. In this randomized, double\u2010blind clinical trial, 120 postmenopausal women with mixed urinary incontinence were randomized to one of the three groups of FHP, placebo, and standard treatment (solifenacin). Frequency, amount of leakage, and score of urinary incontinence as well as the QOL were measured at the end of the second and fourth weeks and 2\u2009weeks after the interruption of the treatment. The ICIQ\u2010UI SF and I\u2010QOL questionnaires were used for the measurements. Mean frequency of urinary incontinence and amount of leakage significantly decreased in the FHP and solifenacin groups in the fourth week compared to the placebo group. In addition, 2\u2009weeks after treatment completion, the effects of the FHP were significant compared to the solifenacin group. Due to the effect of FHP on improving the QOL and also the prolonged effect of this drug, the use of FHP in urinary incontinence, as a complementary treatment could be suggested.<\/jats:p>","DOI":"10.1002\/ptr.7691","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T01:56:02Z","timestamp":1669686962000},"page":"1754-1770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of frankincense\u2010based herbal product in urinary incontinence: A randomized, double\u2010blind, placebo\u2010 and active\u2010controlled clinical trial"],"prefix":"10.1002","volume":"37","author":[{"given":"Mahbubeh","family":"Karbalaiee","sequence":"first","affiliation":[{"name":"Physiology Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"},{"name":"Department of Traditional Medicine, Faculty of Persian Medicine Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azar","family":"Daneshpajooh","sequence":"additional","affiliation":[{"name":"Department of Urology, Shahid Bahonar Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Khanjani","sequence":"additional","affiliation":[{"name":"Neurology Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Sohbati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Research Development Unit, Afzalipour Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnaz","family":"Mehrabani","sequence":"additional","affiliation":[{"name":"Physiology Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0132-9855","authenticated-orcid":false,"given":"Mehrzad","family":"Mehrbani","sequence":"additional","affiliation":[{"name":"Herbal and Traditional Medicines Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Mehrabani","sequence":"additional","affiliation":[{"name":"Herbal and Traditional Medicines Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.21786\/bbrc\/10.4\/2"},{"key":"e_1_2_8_3_1","volume-title":"ICH Q1A (R2) on stability testing of new drug substances and drug products","year":"2003"},{"key":"e_1_2_8_4_1","volume-title":"Qarabadin\u2010e\u2010Kabir","author":"Aghili Khorasani M. 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