{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:59:14Z","timestamp":1792094354281,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T00:00:00Z","timestamp":1673654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increased urinary incontinence is one of the most common changes during menopause. This study aimed to investigate the effect of <jats:italic>Nigella sativa L.<\/jats:italic> seed oil on urinary incontinence and quality of life (QoL) (primary outcomes) and sexual function (secondary outcome) in menopausal women. In this triple\u2010blind randomized controlled trial, 60 women in Tabriz\u2010Iran were equally allocated into two treatment and control groups using block randomization. The women applied 2\u20133 drops of <jats:italic>Nigella sativa L.<\/jats:italic> seed oil or placebo on their stomachs below the novel twice a day for 8\u2009weeks. The data collection instruments were completed at baseline and just after the intervention. After intervention, the mean rank score of mixed urinary incontinence was significantly lower (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.04) and the mean score of the incontinence\u2010QoL was significantly higher (mean difference 12.63, 95% CI 2.33 to 22.93; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.017) in the treatment group than the control group. However, there were no significant differences in stress incontinence, urge incontinence, sexual function, and menopause\u2010specific QoL of women between the groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). The results indicated the positive effect of the <jats:italic>Nigella sativa L.<\/jats:italic> seed oil on mixed incontinence and incontinence\u2010QoL; nevertheless, to make a certain conclusion, further studies are required.<\/jats:p>","DOI":"10.1002\/ptr.7725","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T15:33:25Z","timestamp":1673710405000},"page":"2012-2023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of <i>Nigella sativa L.<\/i> seed oil on urinary incontinence and quality of life in menopausal women: A triple\u2010blind randomized controlled trial"],"prefix":"10.1002","volume":"37","author":[{"given":"Afsaneh","family":"Alizadeh","sequence":"first","affiliation":[{"name":"Department of Midwifery, Faculty of Nursing and Midwifery Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakineh","family":"Mohammah\u2010Alizadeh\u2010Charandabi","sequence":"additional","affiliation":[{"name":"Menopause Andropause Research Center Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laleh","family":"Khodaie","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-4309","authenticated-orcid":false,"given":"Mojgan","family":"Mirghafourvand","sequence":"additional","affiliation":[{"name":"Professor, Social Determinants of Health Research Center, Faculty of Nursing and Midwifery Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,14]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"24","article-title":"Effect of fennel vaginal cream on sexual function in postmenopausal women: A double blind randomized controlled trial","volume":"11","author":"Abedi P.","year":"2018","journal-title":"Journal of Medicine and Life"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02243-4"},{"key":"e_1_2_11_4_1","first-page":"130","article-title":"The effect of hop (Humulus lupulus L.) on early menopausal symptoms and hot flashes: A randomized placebo\u2010controlled trial","volume":"23","author":"Aghamiri V.","year":"2016","journal-title":"Complementary Therapies in Medicine"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383062"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901296"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20041"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2019.100259"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0b013e31823efd47"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.07.037"},{"issue":"10","key":"e_1_2_11_11_1","article-title":"Oestrogen therapy for urinary incontinence in post\u2010menopausal women","volume":"2012","author":"Cody J. 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