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Myricetin (Myr), a bioactive flavonoid, exhibits antiinflammatory activities. Our results showed that treatment with Myr could alleviate ICU symptoms, including a decrease in the number of wheals and scratching, and inhibit ear swelling in the IgE\/DNFB\u2010induced mice. The serum level of IgE, histamine, interleukin (IL)\u20104, TNF\u2010\u03b1, and MCP\u20101 were reduced in Myr\u2010treated mice. Myr also attenuated mast cells (MCs) degranulation and H\u2010PGDS, TSLP, IL\u201033, PI3K, Akt, and NF\u2010\u03baB mRNA levels in ICU model. The IgE\u2010mediated anaphylaxis mouse models demonstrated anti\u2010allergic effects of Myr. In vitro analysis showed that Myr reduced IgE\u2010induced calcium (Ca<jats:sup>2+<\/jats:sup>) influx, suppressed degranulation, and chemokine release in LAD2 cells (human primary mast cells). Myr can significantly inhibited PLC\u03b31, Akt, NF\u2010\u03baB, and p38 phosphorylation. In conclusion, the study demonstrated that Myr alleviate ICU symptoms and inhibit mast cell activation via PI3K\/Akt\/NF\u2010\u03baB signal pathway.<\/jats:p>","DOI":"10.1002\/ptr.7726","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T03:51:53Z","timestamp":1674013913000},"page":"2024-2035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Myricetin alleviated immunologic contact urticaria and mast cell degranulation via the <scp>PI3K<\/scp>\/Akt\/<scp>NF\u2010\u03baB<\/scp> pathway"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-4358","authenticated-orcid":false,"given":"Shiting","family":"Hu","sequence":"first","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an People's Republic of 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