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Medicinal plants traditionally used for problems associated with ageing are emerging as a therapeutic resource. The main aim is to give a proposal for use and future research based on scientific knowledge and tradition. A literature search was conducted in several searchable databases. The keywords used were related to neurodegenerative dementias, ageing and medicinal plants. Boolean operators and filters were used to focus the search. As a result, there is current clinical and preclinical scientific information on 49 species used in traditional medicine for ageing\u2010related problems, including neurodegenerative dementias. There are preclinical and clinical scientific evidences on their properties against protein aggregates in the central nervous system and their effects on neuroinflammation, apoptosis dysregulation, mitochondrial dysfunction, gabaergic, glutamatergic and dopaminergic systems alterations, monoamine oxidase alterations, serotonin depletion and oestrogenic protection. In conclusion, the potential therapeutic effect of the different medicinal plants depends on the type of neurodegenerative dementia and its stage of development, but more clinical and preclinical research is needed to find better, safer and more effective treatments.<\/jats:p>","DOI":"10.1002\/ptr.7727","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T03:53:40Z","timestamp":1674532420000},"page":"1176-1211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal"],"prefix":"10.1002","volume":"37","author":[{"given":"Nuria","family":"Acero","sequence":"first","affiliation":[{"name":"Pharmaceutical and Health Sciences Department, Pharmacy Faculty San Pablo\u2010CEU University, CEU Universities  Boadilla del Monte Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ortega","sequence":"additional","affiliation":[{"name":"Pharmacology, Pharmacognosy and Botany Department, Pharmacy Faculty Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Villagrasa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera\u2010CEU CEU Universities  Alfara del Patriarca Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Leon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera\u2010CEU CEU Universities  Alfara del Patriarca Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Mu\u00f1oz\u2010Mingarro","sequence":"additional","affiliation":[{"name":"Chemistry and Biochemistry Department, Pharmacy Faculty, San Pablo\u2010CEU University CEU Universities  Boadilla del Monte Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encarna","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera\u2010CEU CEU Universities  Alfara del Patriarca Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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