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Curcumin (CUR) with antiinflammatory, antioxidant, and antitumor activities has been associated with therapeutic benefits against various cancers. It can regulate multiple signaling pathways, such as PI3K\/Akt, Wnt\/\u03b2\u2010catenin, JAK\/STAT, p53, MAPKs, and NF\u2010\u0138B, which are involved in cancer cell proliferation, metastasis, apoptosis, angiogenesis, and autophagy. Due to its rapid metabolism, poor oral bioavailability, and low solubility in water, CUR application in clinical practices is restricted. To overcome these limitations, nanotechnology\u2010based delivery systems have been applied to use CUR nanoformulations with added benefits, such as reducing toxicity, improving cellular uptake, and targeting tumor sites. Besides the anticancer activities of CUR in combating various cancers, especially liver cancer, here we focused on the CUR nanoformulations, such as micelles, liposomes, polymeric, metal, and solid lipid nanoparticles, and others, in the treatment of liver cancer.<\/jats:p>","DOI":"10.1002\/ptr.7757","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T13:19:28Z","timestamp":1678281568000},"page":"1624-1639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Curcumin in the treatment of liver cancer: From mechanisms of action to nanoformulations"],"prefix":"10.1002","volume":"37","author":[{"given":"Sulieman Ibraheem","family":"Shelash Al\u2010Hawary","sequence":"first","affiliation":[{"name":"Department of Business Administration, Business School Al al\u2010Bayt University  Mafraq Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saade","family":"Abdalkareem Jasim","sequence":"additional","affiliation":[{"name":"Medical Laboratory Techniques Department Al\u2010maarif University College  Al\u2010Anbar\u2010Ramadi Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"M. 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