{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:44:06Z","timestamp":1792806246561,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH275"],"award-info":[{"award-number":["ZR2022MH275"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["202102140601019"],"award-info":[{"award-number":["202102140601019"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease around the world, imposing severe threats on human health. Unfortunately, no clinically approved drugs are available for use as yet. Baicalin (BA) is reported to have hepatoprotective effects, and it is not clear whether BA can treat NAFLD and how. Here, a high\u2010fat diet (HFD)\u2010induced NAFLD mouse model was established to explore the protective roles and mechanisms of BA against HFD\u2010induced NAFLD. Physiochemical results showed that BA exhibited significantly protective effects against HFD\u2010induced NAFLD in mice. Liver transcriptomic analysis revealed that BA attenuated HFD\u2010induced NAFLD via activating AMPK pathway, which was confirmed by the AMPK inhibitor Compound C. Additionally, the expression changes of AMPK downstream genes demonstrated that BA exerted ameliorative effects against NAFLD through AMPK\u2010mediated inhibition of SREBP1 and NF\u2010\u03baB pathways, and activation of Nrf2 pathway. Taken together, our study reveals the protective roles of BA against HFD\u2010caused NAFLD through AMPK\u2010mediated modulation of SREBP1\/Nrf2\/NF\u2010\u03baB pathways, suggesting that BA has potential drug development implications. Most importantly, our study creates a paradigm through the combination of molecular biology and bioinformatics for further studies of action mechanisms of biomolecules combating diseases.<\/jats:p>","DOI":"10.1002\/ptr.7762","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T11:42:21Z","timestamp":1675856541000},"page":"2405-2418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Baicalin ameliorates high fat diet\u2010induced nonalcoholic fatty liver disease in mice via adenosine monophosphate\u2010activated protein kinase\u2010mediated regulation of <scp>SREBP1<\/scp>\/Nrf2\/<scp>NF\u2010\u03baB<\/scp> signaling pathways"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-5324","authenticated-orcid":false,"given":"Yanxia","family":"Gao","sequence":"first","affiliation":[{"name":"Shanxi Key Lab for Modernization of TCVM, College of Veterinary Medicine Shanxi Agricultural University  Taigu China"},{"name":"College of Life Science Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Tai'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Biological and Brewing Engineering Taishan University  Tai'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanxi Key Lab for Modernization of TCVM, College of Veterinary Medicine Shanxi Agricultural University  Taigu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Schubot Exotic Bird Health Center Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research, Queen's Medical Research Institute The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanxi Key Lab for Modernization of TCVM, College of Veterinary Medicine Shanxi Agricultural University  Taigu China"},{"name":"Laboratory Animal Center Shanxi Agricultural University  Taigu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[{"name":"Shanxi Key Lab for Modernization of TCVM, College of Veterinary Medicine Shanxi Agricultural University  Taigu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuohai","family":"Fan","sequence":"additional","affiliation":[{"name":"Shanxi Key Lab for Modernization of TCVM, College of Veterinary Medicine Shanxi Agricultural University  Taigu China"},{"name":"Laboratory Animal Center Shanxi Agricultural University  Taigu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2030-5587","authenticated-orcid":false,"given":"Hongquan","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Key Lab for Modernization of TCVM, College of Veterinary Medicine Shanxi Agricultural University  Taigu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.124"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.08.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21515"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0454-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.05.002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.188"},{"issue":"5","key":"e_1_2_11_8_1","first-page":"2885","article-title":"Anticancer, antiradical and antioxidative actions of novel Antoksyd S and its major components, baicalin and baicalein","volume":"22","author":"Ciesielska E.","year":"2002","journal-title":"Anticancer 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