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A comprehensive online search was performed in Scopus, PubMed, ISI Web of Science, and Google Scholar until March 2022 to identify trials that investigated the effects of nano\u2010curcumin in patients with COVID\u201019. Eight studies comprising 569 patients were included in this review. Compared with placebo, nano\u2010curcumin had no significant effect on C\u2010reactive protein (CRP) and high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and interleukin\u20106 (IL\u20106). However, gene expression of IL\u20106 and gene expression as well as secretion of interleukin\u20101 beta (IL\u20101\u03b2) significantly decreased following nano\u2010curcumin intervention. Nano\u2010curcumin had beneficial effects on fever, cough, chills, myalgia, and olfactory and taste disturbances. The duration of hospitalization and mortality rate were significantly lower in the nano\u2010curcumin group compared with the control group. Lymphocyte count was significantly increased after curcumin supplementation. Nano\u2010curcumin also had favorable effects on O<jats:sub>2<\/jats:sub> saturation, sputum, chest pain, wheeze, and dyspnea in patients with COVID\u201019. No major adverse effects were reported in response to nano\u2010curcumin supplementation. In summary, the results of this systematic review of clinical trials suggested that nano\u2010curcumin supplementation has beneficial effects on inflammation, respiratory function, disease manifestations, and complications in patients with COVID\u201019 viral infection.<\/jats:p>","DOI":"10.1002\/ptr.7778","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T12:14:28Z","timestamp":1676636068000},"page":"1663-1677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The effectiveness of nano\u2010curcumin on patients with <scp>COVID<\/scp>\u201019: A systematic review of clinical trials"],"prefix":"10.1002","volume":"37","author":[{"given":"Mehrnaz","family":"Shojaei","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Community Nutrition School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan 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