{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:14:32Z","timestamp":1775855672924,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160825"],"award-info":[{"award-number":["82160825"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Danggui Buxue Tang (DBT) is a well\u2010known Chinese herbal recipe often prescribed in clinical treatment for menopausal and cardiovascular symptoms. 5\u2010Fluorouracil (5\u2010FU) is a chemotherapy drug that treats several cancers; however, it causes severe adverse effects and multidrug resistance. Combining natural medications can reduce the side effects of 5\u2010FU use. Hence, we aimed to determine the role of DBT in strengthening the anticancer capabilities of 5\u2010FU in a cultured colorectal adenocarcinoma cell line (HT\u201029 cell) and xenograft nude mice. HT\u201029 cells cultured with DBT did not exhibit cytotoxicity. However, co\u2010administration of DBT with 5\u2010FU significantly increased apoptosis and the expression of apoptotic markers. The inhibition of proliferation induced by DBT and 5\u2010FU was shown to be mediated by c\u2010Jun N\u2010terminal kinase signaling. In addition, the potentiation effect of 5\u2010FU and DBT was demonstrated in reducing tumor size, expressions of Ki67 and CD34 in HT\u201029 xenograft mice. This finding suggests that DBT can work with 5\u2010FU as a novel chemotherapeutic strategy for treating colon cancer.<\/jats:p>","DOI":"10.1002\/ptr.7782","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T10:54:16Z","timestamp":1677063256000},"page":"2864-2876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Danggui Buxue Tang potentiates the cytotoxicity of 5\u2010fluorouracil on colorectal adenocarcinoma cells: A signaling mediated by c\u2010Jun N\u2010terminal kinase"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-4103","authenticated-orcid":false,"given":"Guowei","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Bioengineering Zunyi Medical University  Zhuhai China"},{"name":"Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and 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