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(Magnoliaceae) as a possible dietary supplement for supporting the treatment of airway pathologies might be of clinical interest. Two commercially available bark extracts (<jats:italic>M<\/jats:italic>. <jats:italic>officinalis<\/jats:italic> extract [MOE]) were characterized by quantitation in honokiol and magnolol content by means of high\u2010performance liquid chromatography with UV detection. MOE effects, as well as those of the reference compounds per se, on some targets connected to airway pathologies (antibacterial\u2010 and lung and trachea relaxing\u2010 activities) were investigated. Results showed that MOE possessed interesting antibacterial activity against <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, and <jats:italic>Streptococcus pneumoniae<\/jats:italic>. This was accompanied by a spasmolytic and antispasmodic activity, possibly owing to its ability to concurrently modulate different targets such as H<jats:sub>1<\/jats:sub>\u2010, \u03b2<jats:sub>2<\/jats:sub>\u2010 and muscarinic receptors and <jats:sc>l<\/jats:sc>\u2010type calcium channels involved in bronchodilation. All these effects were directly related to the MOE content in honokiol and magnolol. 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