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Curcumin, a powerful herbal polyphenol, exerts inhibitory effects on cancer cell proliferation, angiogenesis, invasion, and metastasis through interaction with different molecular targets. However, the clinical use of curcumin is limited due to poor solubility in water and metabolism in the liver and intestine. The synergistic effects of curcumin with some phytochemicals such as resveratrol, quercetin, epigallocatechin\u20103\u2010gallate, and piperine can improve its clinical efficacy in cancer treatment. The present review specifically focuses on anticancer mechanisms related to the co\u2010administration of curcumin with other phytochemicals, including resveratrol, quercetin, epigallocatechin\u20103\u2010gallate, and piperine. According to the molecular evidence, the phytochemical combinations exert synergistic effects on suppressing cell proliferation, reducing cellular invasion, and inducing apoptosis and cell cycle arrest. This review also emphasizes the significance of the co\u2010delivery vehicles\u2010based nanoparticles of such bioactive phytochemicals that could improve their bioavailability and reduce their systemic dose. Further high\u2010quality studies are needed to firmly establish the clinical efficacy of the phytochemical combinations.<\/jats:p>","DOI":"10.1002\/ptr.7794","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T05:38:35Z","timestamp":1678253915000},"page":"1688-1702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Co\u2010administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets"],"prefix":"10.1002","volume":"37","author":[{"given":"Niloofar","family":"Ghobadi","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1406-0595","authenticated-orcid":false,"given":"Ahmad","family":"Asoodeh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"2139","article-title":"Curcumin decreases epithelial\u2010mesenchymal transition by a Pirin\u2010dependent mechanism in cervical cancer cells","volume":"42","author":"Aedo\u2010Aguilera V.","year":"2019","journal-title":"Oncology Reports"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.11.22"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1380208"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1767167"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14111068"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12296"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00050"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24042"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0171"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116090"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1723"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132091"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5101\/nbe.v6i2.p47-59"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327109107002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b06155"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"39","article-title":"Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down\u2010regulation of STAT3\u2010NF\u03baB signaling","volume":"35","author":"Chung S. 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