{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:02:27Z","timestamp":1792252947942,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"GuangDong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2021B1515140051"],"award-info":[{"award-number":["2021B1515140051"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic cardiomyopathy (DCM), one of the major complications of type 2 diabetes, is a leading cause of heart failure and death in advanced diabetes. Although there is an association between DCM and ferroptosis in cardiomyocytes, the internal mechanism of ferroptosis leading to DCM development remains unknown. CD36 is a key molecule in lipid metabolism that mediates ferroptosis. Astragaloside IV (AS\u2010IV) confers various pharmacological effects such as antioxidant, anti\u2010inflammatory, and immunomodulatory. In this study, we demonstrated that AS\u2010IV was able to recover the dysfunction of DCM. In vivo experiments showed that AS\u2010IV ameliorated myocardial injury and improved contractile function, attenuated lipid deposition, and decreased the expression level of CD36 and ferroptosis\u2010related factors in DCM rats. In vitro experiments showed that AS\u2010IV decreased CD36 expression and inhibited lipid accumulation and ferroptosis in PA\u2010induced cardiomyocytes. The results demonstrated that AS\u2010IV decreased cardiomyocyte injury and myocardial dysfunction by inhibiting ferroptosis mediated by CD36 in DCM rats. Therefore, AS\u2010IV regulated the lipid metabolism of cardiomyocytes and inhibited cellular ferroptosis, which may have potential clinical value in DCM treatment.<\/jats:p>","DOI":"10.1002\/ptr.7798","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T01:23:58Z","timestamp":1678238638000},"page":"3042-3056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Astragaloside <scp>IV<\/scp> attenuates myocardial dysfunction in diabetic cardiomyopathy rats through downregulation of <scp>CD36<\/scp>\u2010mediated ferroptosis"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0646-1695","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine  Guangzhou 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