{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:13:53Z","timestamp":1787987633696,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Formononetin (FMN) is a phytoestrogen that belongs to the isoflavone family. It has antioxidant and anti\u2010inflammatory effects, as well as, many other biological activities. Existing evidence has aroused interest in its ability to protect against osteoarthritis (OA) and promote bone remodeling. To date, research on this topic has not been thorough and many issues remain controversial. Therefore, the purpose of our study was to explore the protective effect of FMN against knee injury and clarify the possible molecular mechanisms. We found that FMN inhibited osteoclast formation induced by receptor activator of NF\u2010\u03baB ligand (RANKL). Inhibition of the phosphorylation and nuclear translocation of p65 in the NF\u2010\u03baB signaling pathway plays a role in this effect. Similarly, during the inflammatory response of primary knee cartilage cells activated by IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , FMN inhibited the NF\u2010\u03baB signaling pathway and the phosphorylation of the ERK and JNK proteins in the MAPK signaling pathway to suppress the inflammatory response. In addition, in vivo experiments showed that both low\u2010 and high\u2010dose FMN had a clear protective effect against knee injury in the DMM (destabilization of the medial meniscus) model, and the therapeutic effect of high\u2010dose FMN was stronger. In conclusion, these studies provide evidence of the protective effect of FMN against knee injury.\n                  <\/jats:p>","DOI":"10.1002\/ptr.7810","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T10:54:30Z","timestamp":1680346470000},"page":"3363-3379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Formononetin improves the inflammatory response and bone destruction in knee joint lesions by regulating the\n                    <scp>NF\u2010kB<\/scp>\n                    and\n                    <scp>MAPK<\/scp>\n                    signaling pathways"],"prefix":"10.1002","volume":"37","author":[{"given":"Kai\u2010nan","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, Lishui Municipal Central Hospital  289 Kuocang Road 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