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Curcumin, a bioactive polyphenol from <jats:italic>Curcuma longa<\/jats:italic>, can improve lipid profile. This study aims to analyze the effects of <jats:italic>Curcuma Longa<\/jats:italic> extract supplementation on lipid profile and lipoprotein subfractions in hemodialysis (HD) patients. This is a longitudinal, double\u2010blind, washout\u2010period randomized clinical trial. The patients were randomized into two groups: the curcumin group (<jats:italic>n<\/jats:italic>\u2009=\u200910) (orange and carrot juice with 2.5\u2009g of <jats:italic>Curcuma Longa<\/jats:italic> extract) and the control group (<jats:italic>n<\/jats:italic>\u2009=\u200911) (juice without curcumin) 3x\/w during HD sessions for 3\u2009months. After the washout period, patients continued the supplementation as a crossover for the same period. The lipid profile was measured using enzymatic assays. The high\u2010density lipoprotein and low\u2010density lipoprotein subfractions analyses were performed using LipoprintTM. In the curcumin group, the triglyceride values tended to decrease with a different triglyceride variation between the pre and post\u2010intervention for the control and curcumin groups of 38.5 (19.8) mg\/dL (<jats:italic>p<\/jats:italic>\u2009=\u20090.06). There was no statistical difference in the others parameters. In conclusion, <jats:italic>Curcuma longa<\/jats:italic> extract may be a good nutritional strategy to reduce triglyceride plasma levels in hemodialysis patients, but it seems ineffective for the other parameter.<\/jats:p>","DOI":"10.1002\/ptr.7814","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T12:31:29Z","timestamp":1681302689000},"page":"3424-3437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of turmeric extract supplementation on the lipid and lipoprotein subfraction profile in hemodialysis patients: A randomised, double\u2010blind, crossover and controlled trial"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-8139","authenticated-orcid":false,"given":"L.","family":"Alvarenga","sequence":"first","affiliation":[{"name":"Graduate Program in Biological Sciences\u2014Physiology Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Lima","sequence":"additional","affiliation":[{"name":"Research, Development, and Innovation Department Apis Flora Indl. Coml. Ltda.  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