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PubMed, Scopus, Web of Science, and Google Scholar were systematically searched for clinical trials that investigated the effect of medicinal plants on cirrhosis. This review includes 11 clinical trials, of which eight studies including 613 patients assessed the effect of silymarin on cirrhosis. Three of six studies showed the beneficial effects of silymarin on aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Two studies including 118 patients investigated the effect of curcumin on cirrhosis, one showing improvement in quality of life and the other showing improvements in alkaline phosphatase (ALP), bilirubin, prothrombin time (PT), and the international normalized ratio (INR). An article including four patients investigated the effect of ginseng on cirrhosis; two patients reported improvement in the Child\u2010Pugh score, and ascites decreased in two. All studies included here reported no or negligible side effects. Results showed that medicinal plants including silymarin, curcumin, and ginseng have beneficial effects on cirrhosis. However, due to the limited number of studies, further high\u2010quality studies are warranted.<\/jats:p>","DOI":"10.1002\/ptr.7816","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T05:44:34Z","timestamp":1684820674000},"page":"3083-3096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of medicinal plants on cirrhosis: A systematic review of clinical trials"],"prefix":"10.1002","volume":"37","author":[{"given":"Sepide","family":"Amini","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-6129","authenticated-orcid":false,"given":"Mohammad","family":"Bagherniya","sequence":"additional","affiliation":[{"name":"Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Anesthesia and Critical Care Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-3917","authenticated-orcid":false,"given":"Alexandra E.","family":"Butler","sequence":"additional","affiliation":[{"name":"Research Department Royal College of Surgeons in Ireland Bahrain  Adliya Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[{"name":"Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Anesthesia and Critical Care Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Applied Biomedical Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Biotechnology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1127743"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6171"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5957"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488712802281240"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.18663"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1990"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7118"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.12.020"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i3.109"},{"key":"e_1_2_14_11_1","first-page":"397","article-title":"Herbs as liver savers\u2010a review","volume":"1","author":"Chaudhary G. 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