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Echinocystic acid (EA), a triterpene, shows anti\u2010inflammatory and antioxidant effects. We predict that EA supplementation can prevent obesity, diabetes, and nonalcoholic steatohepatitis. To test our hypothesis, we investigated the effects of EA supplementation on mice with HFD\u2010induced obesity in vivo and in vitro by adding EA to the diet of mice and the medium of HepG2 cells, the protein target of EA was analyzed by molecular docking. The results showed that EA ameliorated obesity and inhibited blood triglyceride and liver triglyceride concentrations than those in the HFD groups. The data on molecular docking indicated that FABP1 was a potential target of EA. Further experimental results confirmed that EA affected the triglyceride level by regulating the function of FABP1. This study may provide a new potential inhibitor for FABP1 and a new strategy for the treatment of obesity.<\/jats:p>","DOI":"10.1002\/ptr.7839","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T11:37:23Z","timestamp":1682336243000},"page":"3617-3630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Echinocystic acid prevents obesity and fatty liver via interacting with<scp>FABP1<\/scp>"],"prefix":"10.1002","volume":"37","author":[{"given":"Lianggui","family":"Xiao","sequence":"first","affiliation":[{"name":"Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Guangxi University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1419-6142","authenticated-orcid":false,"given":"Yixing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Guangxi University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-4953","authenticated-orcid":false,"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i19.2083"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/75068"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.048"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.12.35"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.653641"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03194597"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6972"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161115666170621080228"},{"key":"e_1_2_10_10_1","article-title":"Therapeutic targeting of hepatic ACSL4 ameliorates non\u2010alcoholic Steatohepatitis in mice","author":"Duan J.","year":"2021","journal-title":"Hepatology, 75,"},{"key":"e_1_2_10_11_1","first-page":"4174","article-title":"Echinocystic acid ameliorates hyperhomocysteinemia\u2010induced vascular endothelial cell injury through regulating NF\u2010kappaB and CYP1A1","volume":"14","author":"Huang C. 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