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Curcumin with its powerful anti\u2010inflammatory and antiviral properties could serve as a possible COVID\u201019 therapy. In this study, a randomized, double\u2010blinded, placebo\u2010controlled trial was performed to investigate the effectiveness and safety of nano\u2010curcumin oral soft gels as a complementary therapy in moderate\u2013severe COVID\u201019 patients. Hydroxychloroquine (HCQ) plus sofosbuvir was routinely administered to all 42 COVID\u201019 patients, who were randomly assigned to receive 140\u2009mg of nano\u2010curcumin or placebo for 14\u2009days. CT scans of the chest were taken, and blood tests were run for all patients at time points of 0, 7, and 14\u2009days. Our results indicated that C\u2010reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels significantly decreased from baseline in the nano\u2010curcumin\u2010treated group on day 7. Furthermore, blood levels of D\u2010dimer, CRP, serum ferritin, ESR, and inflammatory cytokines including IL\u20106, IL\u20108, and IL\u201010 decreased more significantly in the nano\u2010curcumin\u2010treated group after 14\u2009days. Additionally, the nano\u2010curcumin group showed significant improvements in chest CT scores, oxygen saturation levels, and hospitalization duration. Based on our data, oral administration of nano\u2010curcumin may be regarded as a promising adjunct treatment for COVID\u201019 patients due to its ability to speed up chest clearance and recovery.<\/jats:p>","DOI":"10.1002\/ptr.7844","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T07:00:15Z","timestamp":1682751615000},"page":"3631-3644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Promising clinical outcomes of nano\u2010curcumin treatment as an adjunct therapy in hospitalized <scp>COVID<\/scp>\u201019 patients: A randomized, double\u2010blinded, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2497-3152","authenticated-orcid":false,"given":"Majid","family":"Sadeghizadeh","sequence":"first","affiliation":[{"name":"Department of Genetics, Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe","family":"Asadollahi","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Jahangiri","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"},{"name":"Department of Molecular Medicine, Institute of Medical Biotechnology National Institute of Genetic Engineering and Biotechnology (NIGEB)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Yadollahzadeh","sequence":"additional","affiliation":[{"name":"Firoozgar Medical &amp; Educational Hospital Department of Internal Medicine School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Mohajeri","sequence":"additional","affiliation":[{"name":"Alborz Nanomed Tech Company  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Afsharpad","sequence":"additional","affiliation":[{"name":"Cancer Control Research Center, Cancer Control Foundation Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhood","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Resin and Additives Institute for Color Science and Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Rezaie","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Firouzgar Hospital, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohana","family":"Eskandari","sequence":"additional","affiliation":[{"name":"Firoozgar Medical &amp; Educational Hospital Department of Internal Medicine School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tavakoli\u2010Ardakani","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Feizabadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Masjedi","sequence":"additional","affiliation":[{"name":"Cancer Control Research Center, Cancer Control Foundation Iran University of Medical Sciences  Tehran Iran"},{"name":"Department of Pulmonary Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Tobacco Control Research Center (TCRC) Iranian Anti\u2010tobacco Association, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,29]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"(FDA) U.S.f.a.d.a. 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