{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:48:20Z","timestamp":1788392900320,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine the pharmaceutical applications, we assessed the evidence from preclinical studies about the hypoglycemic, hypolipidemic, and antioxidant potential of <jats:italic>Pistacia atlantica<\/jats:italic> (PA) as a natural source for prevention and treatment of diabetes. A comprehensive literature search of the articles published until March 12, 2022 was conducted on PubMed, Embase, Web of Sciences, and Scopus databases, using relevant keywords. This meta\u2010analysis included 12 articles that examined the blood glucose (BG), insulin, homeostatic model assessment for insulin resistance (HOMA\u2010IR), triglyceride (TG), total cholesterol (TC), high\u2010density lipoprotein cholesterol (HDL\u2010C), malondialdehyde (MDA) and superoxide dismutase (SOD). A random\u2010effects model was used to estimate the pooled effect size. Findings indicated that PA supplementation significantly decreased BG, HOMA\u2010IR, TC, TG, and MDA, and increased insulin and SOD in diabetic animals compared with control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). However, PA supplementation had no significant effects on HDL\u2010C (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). The subgroup analysis also confirmed the beneficial effect of PA supplementation with longer duration (&gt;4\u2009weeks) and higher doses (\u2265100\u2009mg\/kg\/day) as well as in the extract type. The studies have heterogeneity associated with methodological diversity and there were some concerns about the risk of bias, especially about randomization and blind outcome assessment. This meta\u2010analysis provided convincing evidence for antidiabetic, hypolipidemic, and antioxidant activity of PA in animals. Further high\u2010quality studies are needed to firmly establish the clinical efficacy of the plant.<\/jats:p>","DOI":"10.1002\/ptr.7898","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T14:24:41Z","timestamp":1688999081000},"page":"3698-3711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antidiabetic, hypolipidemic, and antioxidant activities of <i>Pistacia atlantica<\/i>: A systematic review and <scp>meta\u2010analysis<\/scp> of preclinical studies"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7587-5264","authenticated-orcid":false,"given":"Razieh","family":"Choghakhori","sequence":"first","affiliation":[{"name":"Razi Herbal Medicines Research Center Faculty of Medicine, Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-7334","authenticated-orcid":false,"given":"Amir","family":"Abbasnezhad","sequence":"additional","affiliation":[{"name":"Nutritional Health Research Center Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2429-1458","authenticated-orcid":false,"given":"Mohammad","family":"Yazdi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Medicine, Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-408X","authenticated-orcid":false,"given":"Hassan","family":"Ahmadvand","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center Faculty of Medicine, Lorestan University of Medical Sciences  Khorramabad Iran"},{"name":"Medicinal Plants and Natural Products Research Center Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113329"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants6040042"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S081"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S011"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1809"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2018.1482577"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14023265"},{"issue":"1","key":"e_1_2_11_9_1","first-page":"28","article-title":"Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin\u2010induced diabetic rats","volume":"25","author":"Behmanesh M. 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The Ukrainian","volume":"90","author":"Shahouzehi B.","year":"2018","journal-title":"Biochemical Journal."},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i3.456"},{"issue":"5","key":"e_1_2_11_46_1","first-page":"420","article-title":"The effects of aqueous extract of wild pistachio (Pistacia atlantica) leaves on diabetic nephropathy in rat","volume":"21","author":"Vazifeshenas\u2010Darmiyan K.","year":"2016","journal-title":"Armaghane Danesh."},{"issue":"4","key":"e_1_2_11_47_1","first-page":"245","article-title":"Combined effect of aerobic training and Pistacia athlantica extract on GLUT\u20104 protein expression and muscle glycogen in diabetic rats","volume":"16","author":"Zarekar M.","year":"2014","journal-title":"Iranian Journal of Endocrinology and Metabolism."}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T08:12:50Z","timestamp":1693987970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/ptr.7898"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7898","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,10]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}