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High\u2010affinity immunoglobulin E (IgE) Fc receptors (Fc\u03b5RI) trigger abnormal activation of MCs. Allergic rhinitis (AR) is an IgE\u2010mediated antigen inhalation reaction that occurs in the nasal mucosa. MC aggravation and dysfunction were observed during the early stages of AR pathogenesis. Herb\u2010derived dictamnine exhibits anti\u2010inflammatory effects. Here, we investigated the pharmacological effects of herb\u2010derived dictamnine on IgE\u2010induced activation of MCs and an ovalbumin (OVA)\u2010induced murine AR model. The results indicated that dictamnine attenuated OVA\u2010induced local allergic reactions and reduced body temperature in OVA\u2010challenged mice with active systemic anaphylaxis. Additionally, dictamnine decreased the frequency of nasal rubbing and sneezing in an OVA\u2010induced murine AR model. Moreover, dictamnine inhibited Fc\u03b5RI\u2010activated MC activation in a dose\u2010dependent manner without causing cytotoxicity, reduced the activation of the tyrosine kinase LYN in LAD2 cells, and downregulated the phosphorylation of PLC\u03b31, IP3R, PKC, Erk1\/2, and Akt, which are downstream of LYN. In conclusion, dictamnine suppressed the OVA\u2010stimulated murine model of AR and activated IgE\u2010induced MCs via the LYN kinase\u2010mediated molecular signaling pathway, suggesting that dictamnine may be a promising treatment for AR.<\/jats:p>","DOI":"10.1002\/ptr.7904","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T05:56:05Z","timestamp":1686981365000},"page":"4236-4250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Anti\u2010inflammatory effect of dictamnine on allergic rhinitis via suppression of the LYN kinase\u2010mediated molecular signaling pathway during mast cell activation"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-4263","authenticated-orcid":false,"given":"Rui","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0833-211X","authenticated-orcid":false,"given":"Yuejin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapan","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Affiliated Hospital of Northwest University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyou","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Public Health Xi'an Jiaotong University Health Science Center  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1823-7164","authenticated-orcid":false,"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(82)90103-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2026583118"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.12.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b01142"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153346"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119341"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111944"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12632"},{"issue":"9","key":"e_1_2_10_10_1","first-page":"544","article-title":"Saline irrigation for allergic rhinitis","volume":"99","author":"Clebak K. 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