{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:58:44Z","timestamp":1787320724105,"version":"build-2736575974"},"reference-count":123,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M710500"],"award-info":[{"award-number":["2022M710500"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["YJ20220058"],"award-info":[{"award-number":["YJ20220058"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205043"],"award-info":[{"award-number":["82205043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High\u2010altitude cardiac injury (HACI) is one of the common tissue injuries caused by high\u2010altitude hypoxia that may be life threatening. Notoginsenoside R1 (NG\u2010R1), a major saponin of Panax notoginseng, exerts anti\u2010oxidative, anti\u2010inflammatory, and anti\u2010apoptosis effects, protecting the myocardium from hypoxic injury. This study aimed to investigate the protective effect and molecular mechanism of NG\u2010R1 against HACI. We simulated a 6000\u2009m environment for 48\u2009h in a hypobaric chamber to create a HACI rat model. Rats were pretreated with NG\u2010R1 (50, 100\u2009mg\/kg) or dexamethasone (4\u2009mg\/kg) for 3\u2009days and then placed in the chamber for 48\u2009h. The effect of NG\u2010R1 was evaluated by changes in Electrocardiogram parameters, histopathology, cardiac biomarkers, oxidative stress and inflammatory indicators, key protein expression, and immunofluorescence. U0126 was used to verify whether the anti\u2010apoptotic effect of NG\u2010R1 was related to the activation of ERK pathway. Pretreatment with NG\u2010R1 can improve abnormal cardiac electrical conduction and alleviate high\u2010altitude\u2010induced tachycardia. Similar to dexamethasone, NG\u2010R1 can improve pathological damage, reduce the levels of cardiac injury biomarkers, oxidative stress, and inflammatory indicators, and down\u2010regulate the expression of hypoxia\u2010related proteins HIF\u20101\u03b1 and VEGF. In addition, NG\u2010R1 reduced cardiomyocyte apoptosis by down\u2010regulating the expression of apoptotic proteins Bax, cleaved caspase 3, cleaved caspase 9, and cleaved PARP1 and up\u2010regulating the expression of anti\u2010apoptotic protein Bcl\u20102 through activating the ERK1\/2\u2010P90RSK\u2010Bad pathway. In conclusion, NG\u2010R1 prevented HACI and suppressed apoptosis via activation of the ERK1\/2\u2010P90RSK\u2010Bad pathway, indicating that NG\u2010R1 has therapeutic potential to treat HACI.<\/jats:p>","DOI":"10.1002\/ptr.7923","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T06:08:51Z","timestamp":1686722931000},"page":"4522-4539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pretreatment with Notoginsenoside\n                    <scp>R1<\/scp>\n                    attenuates high\u2010altitude hypoxia\u2010induced cardiac injury via activation of the\n                    <scp>ERK1<\/scp>\n                    \/\n                    <scp>2\u2010P90RSK\u2010Bad<\/scp>\n                    signaling pathway in rats"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4768-6527","authenticated-orcid":false,"given":"Sijing","family":"Zhao","sequence":"first","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"},{"name":"School of Traditional Chinese Medicine Chongqing Medical and Pharmaceutical College  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jia","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zherui","family":"Shen","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Pei","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demei","family":"Huang","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-4176","authenticated-orcid":false,"given":"Yilan","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6475-2349","authenticated-orcid":false,"given":"Shihua","family":"Shi","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5877-8913","authenticated-orcid":false,"given":"Yacong","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-9652","authenticated-orcid":false,"given":"Zhenxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.11.004"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"64","article-title":"High altitude and free radicals","volume":"3","author":"Bakonyi T.","year":"2004","journal-title":"Journal of Sports Science and Medicine"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.650796"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00390"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2015.0098"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.873867"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.616139"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"485","article-title":"Metabolites of Notoginsenoside R1 in rats","volume":"21","author":"Chen G.","year":"2010","journal-title":"SHIZHEN GUOYI GUOYAO"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-015983"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.680636"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.10.016"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.933659"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1556\/2060.105.2018.3.23"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00139"},{"key":"e_1_2_11_16_1","first-page":"12","volume-title":"Chinese pharmacopoeia","author":"Commission C. P.","year":"2020"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14122"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.023"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602235103"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.44"},{"issue":"10","key":"e_1_2_11_21_1","first-page":"1327","article-title":"Protective effect of salidroside against high altitude hypoxia\u2010induced brain injury in rats","volume":"31","author":"Dong X.","year":"2015","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012656"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.602183"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910283"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261792"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1419-2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311983"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01645-8"},{"issue":"4","key":"e_1_2_11_29_1","first-page":"348","article-title":"Effect of intracoronary injection with xuesaitong in treating post\u2010PCI slow\u2010reflow phenomenon in patients with ST\u2010segment elevation myocardial infarction","volume":"30","author":"Gan L. J.","year":"2010","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200828"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.05.006"},{"key":"e_1_2_11_32_1","first-page":"37","article-title":"Study on the safety of water\u2010extracted Panax notoginseng saponins capsules","volume":"05","author":"Geng J.","year":"2006","journal-title":"Yunnan Journal of Traditional Chinese Medicine"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500197"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S390975"},{"issue":"1","key":"e_1_2_11_35_1","first-page":"36","article-title":"Study on Notoginsenoside R1 regulates AMPK\/Nrf\u20102\/HO\u20101 SignalingPathway to relieve myocardial damage in rats with coronary heart disease","volume":"38","author":"Guo W.","year":"2021","journal-title":"Chinese Journal of Modern Applied Pharmacy"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416646761"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-006-0395-7"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.974775"},{"key":"e_1_2_11_39_1","first-page":"47","article-title":"HIF\u2010mediated innate immune responses: Cell signaling and therapeutic implications","volume":"2","author":"Harris A. J.","year":"2014","journal-title":"Hypoxia (Auckl)"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8802513"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1998139"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7432797"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600240RR"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111138"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12971"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.730579"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211025589"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00336"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12351"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.05.038"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4781"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10572"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.97"},{"key":"e_1_2_11_54_1","article-title":"Rhodiola crenulata extract alleviates hypoxic pulmonary edema in rats","volume":"2013","author":"Lee S. Y.","year":"2013","journal-title":"Evidence\u2010based Complementary and Alternative Medicine"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102384"},{"issue":"31","key":"e_1_2_11_56_1","first-page":"2932","article-title":"Acute high\u2010altitude hypoxic brain injury: Identification of ten differential proteins","volume":"8","author":"Li J.","year":"2013","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100596"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13258-020-00999-5"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S240511"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16995"},{"issue":"24","key":"e_1_2_11_61_1","first-page":"2950","article-title":"Study on effect of promoting blood circulation drugs components in treating unstable angina in patients with blood stasis inflammatory levels","volume":"33","author":"Liu X.","year":"2008","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.687394"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28194"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2012.02.006"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i11.1156"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-1192"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6578578"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001803"},{"issue":"5","key":"e_1_2_11_69_1","first-page":"296","article-title":"The influence of hypoxia inducible factor\u20101 alpha expression on apoptosis and proliferation of T lymphocyte in the Peyer's patches after burn with delayed fluid resuscitation in rats at high altitude","volume":"21","author":"Ma M.","year":"2009","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew286"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.16192"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00752"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2010.03.004"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13271"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.013"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.01.016"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181389"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-021-2056-1"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx720"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22925"},{"issue":"22","key":"e_1_2_11_81_1","first-page":"15","article-title":"A systematic review of electrocardiographic changes in healthy high\u2010altitude populations","volume":"1050","author":"Parodi J. B.","year":"2022","journal-title":"Trends in Cardiovascular Medicine"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111083"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.624544"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP282772"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.676782"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.07.024"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i16.4120"},{"issue":"3","key":"e_1_2_11_88_1","first-page":"1","article-title":"Development and regression of right heart ventricular hypertrophy: Biochemical and morphological aspects","volume":"76","author":"Schneider M.","year":"1987","journal-title":"Zeitschrift f\u00fcr Kardiologie"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20182197"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002070"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111669"},{"issue":"6","key":"e_1_2_11_92_1","article-title":"Interventions for treating acute high altitude illness","volume":"6","author":"Simancas\u2010Racines D.","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00678"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12063"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027324"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18041692"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2010"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taad026"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00480.2018"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4848015"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448652"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7834252"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.914344"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.39414"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/jramc-157-01-10"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9583268"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76156-5"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.06.036"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00976-3"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c03282"},{"issue":"10","key":"e_1_2_11_111_1","article-title":"Vasoconstrictor mechanisms in chronic hypoxia\u2010induced pulmonary hypertension: Role of oxidant signaling","volume":"9","author":"Yan S.","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101742"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2021.114342"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90760.2008"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2013.12.002"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01227"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00551.x"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02836469"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.10.041"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12029"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.10.030"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.04.013"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113828"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1069212"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T02:28:34Z","timestamp":1697509714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,14]]},"references-count":123,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/ptr.7923"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7923","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,14]]},"assertion":[{"value":"2023-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}