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However, the neuroprotective mechanism of OEA on motor function recovery after stroke still is unexplored. Therefore, the aim of this study was to explore the effects of OEA treatment on angiogenesis, neurogenesis, and white matter repair in the peri\u2010infarct region after cerebral ischemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Procedure<\/jats:title>\n                    <jats:p>The adult male rats were subjected to 2\u2009h of middle cerebral artery occlusion. The rats were treated with 10 and 30\u2009mg\/kg OEA or vehicle daily starting from day 2 after ischemia induction until they were sacrificed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results and Conclusions<\/jats:title>\n                    <jats:p>The results revealed that OEA increased cortical angiogenesis, neural progenitor cells (NPCs) proliferation, migration, and differentiation. OEA treatment enhanced the survival of newborn neurons and oligodendrogenesis, which eventually repaired the cortical neuronal injury and improved motor function after ischemic stroke. Meanwhile, OEA treatment promoted the differentiation of oligodendrocyte progenitor cells (OPCs) and oligodendrogenesis by activating the PPAR\u03b1 signaling pathway. Our results showed that OEA restores motor function by facilitating cortical angiogenesis, neurogenesis, and white matter repair in rats after ischemic stroke. Therefore, we demonstrate that OEA facilitates functional recovery after ischemic stroke and propose the hypothesis that the long\u2010term application of OEA mitigates the disability after stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ptr.7970","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T01:43:00Z","timestamp":1694569380000},"page":"5341-5353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oleoylethanolamide ameliorates motor dysfunction through\n                    <scp>PPAR\u03b1<\/scp>\n                    \u2010mediates oligodendrocyte differentiation and white matter integrity after ischemic stroke"],"prefix":"10.1002","volume":"37","author":[{"given":"Rengong","family":"Zhuo","sequence":"first","affiliation":[{"name":"The Fifth Hospital of Xiamen &amp; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmao","family":"Song","sequence":"additional","affiliation":[{"name":"The Fifth Hospital of Xiamen &amp; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"The Fifth Hospital of Xiamen &amp; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoshu","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Fifth Hospital of Xiamen &amp; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen 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