{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:54:12Z","timestamp":1789390452240,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["199373"],"award-info":[{"award-number":["199373"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One of the most prevalent ovulation disorders is polycystic ovarian syndrome (PCOS). According to the anti\u2010inflammatory and beneficial effects of propolis, this triple\u2010blind controlled trial was designed to evaluate the effect of propolis on metabolic factors, high\u2010sensitivity C\u2010reactive protein, and testosterone in women with PCOS. Recruited patients from the gynecologist clinic were randomized based on a stratified permuted four\u2010block randomization procedure to supplement with propolis tablets, two tablets\/day (500\u2009mg propolis\/day) (<jats:italic>n<\/jats:italic>\u2009=\u200930) or identical placebo tablets (<jats:italic>n<\/jats:italic>\u2009=\u200930) for 12\u2009weeks in 2021 until 2022. Data were collected using a demographic questionnaire, blood samples, and a checklist to record the measured parameters. A total of 57 patients completed the trial. ANCOVA test showed that hip circumference (HC)) <jats:italic>p<\/jats:italic>\u2009=\u20090.03), fasting insulin (<jats:italic>p<\/jats:italic>\u2009=\u20090.007), homeostatic model assessment for insulin resistance (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), testosterone (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), and low\u2010density lipoprotein (LDL)\/high\u2010density lipoprotein (HDL) (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) were significantly decreased in the propolis versus the placebo group after adjustment for confounders. Although fasting blood glucose (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) decreased significantly in the propolis group compared to the placebo, after adjusting for confounders, significance was lost (<jats:italic>p<\/jats:italic>\u2009=\u20090.09). Supplementation with propolis elicited positive effects on fasting insulin and insulin resistance, in addition to reducing the testosterone level, LDL\/HDL, and HC, in PCOS women.<\/jats:p>","DOI":"10.1002\/ptr.7977","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T07:39:36Z","timestamp":1693640376000},"page":"5366-5377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The effects of propolis supplementation on high\u2010sensitivity C\u2010reactive protein, testosterone hormone, and metabolic profile in women with polycystic ovary syndrome: A randomized, triple\u2010blinded, placebo\u2010controlled clinical trial"],"prefix":"10.1002","volume":"37","author":[{"given":"Elahe","family":"Abbasi","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Bagherniya","sequence":"additional","affiliation":[{"name":"Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Anesthesia and Critical Care Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-3743","authenticated-orcid":false,"given":"Davood","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Nutritional Sciences Department, School of Nutrition Sciences and Food Technology Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatav","family":"Ghasemi\u2010Tehrani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Abbaspour","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cain C. 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