{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:02:13Z","timestamp":1785733333039,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension is a serious concern as it is one of the causes of kideny failure and pulmonary fibrosis. An important therapeutic strategy for treating chronic hypertension is to inhibit the angiotensin converting enzyme (ACE). ACE inhibition reduces kidney damage, pulmonary artery pressure, and high blood pressure. Due to their high efficacy and low risk of side effects, natural renin\u2010angiotensin system inhibitors have drawn increasing attention over the past decades. Alkaloids, amino acids, anthocyanidins, flavonoids, glucosinolates, isoflavonoids, phenolic acids, polyphenolics, and triterpenoids are among the bioactive metabolites pocessing an impressive ACE inhibitory activity. Many herbs including <jats:italic>Rosmarinus officinalis<\/jats:italic>, <jats:italic>Hibiscus sabdariffa<\/jats:italic>, <jats:italic>Curcuma longa<\/jats:italic>, <jats:italic>Rauwolfia serpentina<\/jats:italic>, <jats:italic>Emblica officinalis<\/jats:italic>, <jats:italic>Cynara scolymus<\/jats:italic>, <jats:italic>Punica granatum<\/jats:italic>, <jats:italic>Mucuna pruriens<\/jats:italic>, <jats:italic>Capsicum annuum<\/jats:italic>, and <jats:italic>Moringa olifera<\/jats:italic> were found having ACE inhibitory activities comparable to captopril and enalpril. These enticing natural ACE inhibitors deserve to be a safeguard medicine against hypertension, respiratory distress syndrome, and chronic kidney diseases. More clinical trials are required before new natural compounds and herbs can be used to treat chronic hypertension and its ramifications, such as respiratory distress syndrome and kidney failure.<\/jats:p>","DOI":"10.1002\/ptr.7987","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T11:42:20Z","timestamp":1694086940000},"page":"5464-5472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Natural <scp>angiotensin converting enzyme<\/scp> inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases"],"prefix":"10.1002","volume":"37","author":[{"given":"Aya","family":"Khaled","sequence":"first","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Heliopolis University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Heliopolis University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mamdouh","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Heliopolis University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hager","family":"Saad","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Heliopolis University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Heliopolis University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Sobhy","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Heliopolis University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Piatti","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miral","family":"Sabry","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed A.","family":"Saad","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Cairo University  Cairo Egypt"},{"name":"Department of Pharmaceutical Sciences College of Pharmacy, Gulf Medical University  Ajman United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-2708","authenticated-orcid":false,"given":"Omar M.","family":"Sabry","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Heliopolis University  Cairo Egypt"},{"name":"Pharmacognosy Department, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Caprioli","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)01355-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2020.1848662"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf072896y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.07.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X0600100507"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.24036\/0201932105856-0-00"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2021.09.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2020.100343"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.996820"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c02117"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134745"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.12691\/jfnr-7-5-3"},{"key":"e_1_2_10_14_1","first-page":"1","article-title":"The difference of celery leaves and bay leaves water to decrease blood pressure among pre\u2010elderly with primary hypertension in public health center Cigugur Tengah","volume":"7","author":"Erisandi T. 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