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DCM can progress to heart failure, which is a significant cause of death in diabetic patients, but currently, there is no effective treatment available. Programmed cell death (PCD) is a genetically regulated form of cell death that includes apoptosis, autophagy, necroptosis, ferroptosis, and pyroptosis. PCD is essential for tissue homeostasis and normal development of the body. DCM is a complex condition, and abnormalities in the cascade of PCD signaling have been observed in its pathological process, suggesting that targeting PCD could be a potential therapeutic strategy. Studies have shown that natural substances can effectively modulate PCD to intervene in the treatment of DCM, and their use is safe. This review explores the role of different forms of PCD in the pathogenesis of DCM and summarizes the research progress in targeting PCD with natural substances to treat DCM. It can serve as a basis for further research and drug development to provide new treatment strategies for DCM patients.<\/jats:p>","DOI":"10.1002\/ptr.7992","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T11:59:05Z","timestamp":1692964745000},"page":"5495-5508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Targeting the programmed cell death (<scp>PCD<\/scp>) signaling mechanism with natural substances for the treatment of diabetic cardiomyopathy (<scp>DCM<\/scp>)"],"prefix":"10.1002","volume":"37","author":[{"given":"Xiaoyu","family":"Xuan","sequence":"first","affiliation":[{"name":"First School of Clinical Medicine Shandong University of Traditional Chinese Medicine  Jinan 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