{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:18:30Z","timestamp":1787962710978,"version":"build-2784847793"},"reference-count":77,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Propolis has gained popularity in recent years because of its beneficial properties, which make it a possible preventative and therapeutic agent as well as a valuable food and cosmetic ingredient. The objective of this study was to evaluate the effects of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis. This randomized, double\u2010blind, placebo\u2010controlled clinical trial was performed among 48 patients diagnosed with rheumatoid arthritis. Subjects were randomly assigned to placebo and intervention groups, supplemented with 1000\u2009mg\/day of propolis for 12\u2009weeks. Cardiovascular risk factors including, high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), monocyte chemoattractant protein (MCP\u20101), Nitric oxide, blood pressure, and lipid profile were assessed pre\u2010and post\u2010intervention. The atherogenic index of plasma value, as well as total cholesterol\/high\u2010density lipoprotein cholesterol (HDL\u2010C), triglyceride\/HDL\u2010C, and non\u2010HDL\u2010C\/HDL\u2010C ratios, were significantly reduced in the intervention group, compared with the placebo group post\u2010intervention (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, there was a significant reduction in the serum level of hs\u2010CRP in the intervention group when compared with the placebo group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Furthermore, propolis supplementation could marginally reduce MCP\u20101 (<jats:italic>p<\/jats:italic>\u2009=\u20090.051). These data indicate that propolis supplementation may be a promising treatment strategy for cardiovascular complications among rheumatoid arthritis patients.<\/jats:p>","DOI":"10.1002\/ptr.7996","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T06:08:25Z","timestamp":1693375705000},"page":"5424-5434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The effect of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis: A double\u2010blind, placebo, controlled randomized clinical trial"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0273-1929","authenticated-orcid":false,"given":"Mona","family":"Maddahi","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Student Research Committee Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0012-716X","authenticated-orcid":false,"given":"Elyas","family":"Nattagh\u2010Eshtivani","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Sciences and Clinical Biochemistry, School of Medicine, Social Determinants of Health Research Center Gonabad University of Medical Science  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadhassan","family":"Jokar","sequence":"additional","affiliation":[{"name":"Rheumatic Diseases Research Center, School of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-1948","authenticated-orcid":false,"given":"Mehdi","family":"Barati","sequence":"additional","affiliation":[{"name":"Department of pathobiology and laboratory sciences North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3081-0488","authenticated-orcid":false,"given":"Hamed","family":"Tabesh","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0583-0412","authenticated-orcid":false,"given":"Mohammad","family":"Safarian","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9708-5466","authenticated-orcid":false,"given":"Maryam","family":"Khosravi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1747-0080.12482"},{"issue":"2","key":"e_1_2_12_3_1","first-page":"205","article-title":"Experimental diabetic nephropathy can be prevented by propolis: Effect on metabolic disturbances and renal oxidative parameters","volume":"22","author":"Abo\u2010Salem O. 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