{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:47:28Z","timestamp":1787600848426,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1063383"],"award-info":[{"award-number":["APP1063383"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kava is a South Pacific plant\u2010based medicine with anxiolytic properties, but little is known about the impact kava has on gene expression or whether gene expression can serve as a marker of kava response. This study aimed to determine whether kava treatment alters the expression of genes with physiological relevance to anxiety pathophysiology and whether the baseline expression of these physiologically relevant genes modifies the efficacy of kava treatment. In this post hoc analysis, we examined the expression of 48 genes relevant to the pathophysiology of anxiety collected from a double\u2010blind randomized controlled trial that assessed the efficacy of kava treatment in generalized anxiety disorder. Peripheral blood gene expression was measured in 71 (34 kava, 37 placebo) adults at baseline and in 40 (19 kava, 21 placebo) after 8\u2009weeks of treatment by reverse transcription polymerase chain reaction (PCR). Results revealed that kava decreased the expression of a subunit of the GABA<jats:sub>A<\/jats:sub>\u2010rho receptor gene (GABRR2) and catechol\u2010O\u2010methyltransferase (COMT), a gene related to catecholamine metabolism. Kava efficacy was not found to be modified by baseline (pretreatment) expression of relevant genes. Although these results did not withstand statistical correction for multiple comparisons and require external validation, they support the notion that kava's mechanism of action includes interaction with GABAergic and catecholaminergic systems.<\/jats:p>","DOI":"10.1002\/ptr.7999","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T09:34:26Z","timestamp":1695893666000},"page":"5897-5903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of kava (<i>Piper methysticum<\/i>) on peripheral gene expression among individuals with generalized anxiety disorder: A <scp>post hoc<\/scp> analysis of a randomized controlled trial"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5276-5249","authenticated-orcid":false,"given":"Lachlan","family":"Cribb","sequence":"first","affiliation":[{"name":"Professorial Unit, The Melbourne Clinic, Department of Psychiatry The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9287-8854","authenticated-orcid":false,"given":"Jerome","family":"Sarris","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute Western Sydney University  Westmead New South Wales Australia"},{"name":"Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8075-9222","authenticated-orcid":false,"given":"Karen M.","family":"Savage","sequence":"additional","affiliation":[{"name":"Department of Psychiatry ACT Health  Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Department of Psychiatry ACT Health  Canberra Australia"},{"name":"School of Clinical Medicine, Discipline of Psychiatry The University of Queensland  Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najwa\u2010Joelle","family":"Metri","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute Western Sydney University  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Scholey","sequence":"additional","affiliation":[{"name":"Centre for Human Psychopharmacology Hawthorn, Swinburne University of Technology  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con","family":"Stough","sequence":"additional","affiliation":[{"name":"Centre for Human Psychopharmacology Hawthorn, Swinburne University of Technology  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad A.","family":"Bousman","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Psychiatry, Physiology &amp; Pharmacology Calgary  Alberta Canada"},{"name":"Department of Psychiatry Parkville  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157700"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(00)00198-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:5:1:027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20262"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu239"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003383"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(01)00330-X"},{"key":"e_1_2_10_9_1","first-page":"9","article-title":"Pharmacotherapy of generalized anxiety disorder","volume":"63","author":"Rickels K.","year":"2002","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867419891246"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2010.522554"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-0986-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30272"},{"key":"e_1_2_10_14_1","first-page":"1","article-title":"Mice: Multivariate imputation by chained equations in R","author":"Buuren S. V.","year":"2011","journal-title":"Journal of Statistical Software"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T16:35:13Z","timestamp":1703781313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/ptr.7999"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7999","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]},"assertion":[{"value":"2022-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}