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Because of these adverse health effects, continual efforts to decrease the prevalence and toxicity of CS are imperative. Until the past decades, the impacts of natural compounds have been under investigation on the harmful effects of CS. Turmeric (<jats:italic>Curcuma longa<\/jats:italic>), a rhizomatous herbaceous perennial plant that belongs to the Zingiberaceae family, is the main source of curcumin. This review is an attempt to find out the current knowledge on CS's harmful effects and protective potential of curcumin in the pulmonary, liver, brain, gastrointestinal, and testis organs. According to the present review, simultaneous consumption of curcumin and CS can attenuate CS toxicities including chronic obstructive pulmonary disease, gastrointestinal toxicity, metabolic diseases, testis injury, and neurotoxicity. Moreover, curcumin suppresses carcinogenesis in the skin, liver, lungs, breast, colon, and stomach. Curcumin mediates these protective effects through antioxidant, anti\u2010inflammatory, anti\u2010apoptotic, and anti\u2010carcinogenicity properties.<\/jats:p>","DOI":"10.1002\/ptr.8035","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T02:09:37Z","timestamp":1697076577000},"page":"98-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The protective effects of curcumin against cigarette <scp>smoke\u2010induced<\/scp> toxicity: A comprehensive review"],"prefix":"10.1002","volume":"38","author":[{"given":"Sahar","family":"Fanoudi","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences Neyshabur University of Medical Sciences  Neyshabur Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohaddeseh Sadat","family":"Alavi","sequence":"additional","affiliation":[{"name":"Pharmacological Research Center of Medicinal Plants Mashhad 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