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Edible polyphenols have been found to play a therapeutic role, particularly in liver injury, liver fibrosis, NAFLD\/NASH, and HCC. In the regulation of liver injury, polyphenols exhibit anti\u2010inflammatory and antioxidant effects, primarily targeting the TGF\u2010\u03b2, NF\u2010\u03baB\/TLR4, PI3K\/AKT, and Nrf2\/HO\u20101 signaling pathways. In the regulation of liver fibrosis, polyphenolic compounds effectively reverse the fibrotic process by inhibiting the activation of hepatic stellate cells (HSC). Furthermore, polyphenolic compounds show efficacy against NAFLD\/NASH by inhibiting lipid oxidation and accumulation, mediated through the AMPK, SIRT, and PPAR\u03b3 pathways. Moreover, several polyphenolic compounds exhibit anti\u2010HCC activity by suppressing tumor cell proliferation and metastasis. This inhibition primarily involves blocking Akt and Wnt signaling, as well as inhibiting the epithelial\u2010mesenchymal transition (EMT). Additionally, clinical trials and nutritional evidence support the notion that certain polyphenols can improve liver disease and associated metabolic disorders. However, further fundamental research and clinical trials are warranted to validate the efficacy of dietary polyphenols.<\/jats:p>","DOI":"10.1002\/ptr.8043","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T23:38:27Z","timestamp":1698104307000},"page":"280-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Human diet\u2010derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-3347","authenticated-orcid":false,"given":"Qichao","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Department of Pharmacy Chinese PLA General Hospital  Beijing 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