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The evidence for curcumin's effects on patients with NAFLD is accumulating; however, meta\u2010analyses have reported mixed results. The current umbrella meta\u2010analysis aimed to assess the present evidence and provide an accurate estimate of the overall effects of curcumin\/turmeric on NAFLD patients. The Web of Science, Scopus, PubMed, ScienceDirect, and Google Scholar databases were searched till March 2023 using MeSH terms and related keywords based on the PICO criteria. Meta\u2010analysis studies evaluating the effects of curcumin\/turmeric supplementation on NAFLD patients that reported the effect sizes (ES) and corresponding confidence intervals (CI) were eligible for inclusion in this study. All articles were screened by considering the eligibility criteria by two independent reviewers and required data were extracted from the included meta\u2010analyses. The meta\u2010analysis was performed utilizing a random\u2010effects model by STATA software. Findings of 11 meta\u2010analyses of 99 randomized controlled trials comprising 5546 participants revealed that curcumin\/turmeric supplementation reduced AST (ES\u2009=\u2009\u22121.072, 95% CI (\u22121.656, \u22120.488), <jats:italic>p<\/jats:italic>\u2009=\u20090.000), ALT (ES\u2009=\u2009\u22120.625, 95% CI (\u22121.170, \u22120.134), <jats:italic>p<\/jats:italic>\u2009=\u20090.014), and TG (ES\u2009=\u2009\u22120.469, 95% CI (\u22121.057, 0.119), <jats:italic>p<\/jats:italic>\u2009=\u20090.128) levels, and HOMA\u2010IR (ES\u2009=\u2009\u22120.291, 95% CI (\u22120.368, \u22120.214), <jats:italic>p<\/jats:italic>\u2009=\u20090.000), BMI (ES\u2009=\u2009\u22120.205, 95% CI (\u22120.304, \u22120.107), <jats:italic>p<\/jats:italic>\u2009=\u20090.000), and WC (ES\u2009=\u2009\u22121.290, 95% CI (\u22122.038, \u22120.541), <jats:italic>p<\/jats:italic>\u2009=\u20090.001) in comparison to the control group. However, the effects of curcumin on GGT, ALP, TC, LDL\u2010C, HDL\u2010C, FBS, and HbA1C levels and body weight were not significant. The findings suggest the beneficial effects of curcumin\/turmeric supplementation in patients with NAFLD, such as improving liver function, decreasing serum TG levels, ameliorating insulin resistance, and reducing general and central obesity. Nevertheless, high\u2010quality research is further required to prove these achievements.<\/jats:p>","DOI":"10.1002\/ptr.8051","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T01:13:15Z","timestamp":1698973995000},"page":"539-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of curcumin\/turmeric supplementation on the liver enzymes, lipid profiles, glycemic index, and anthropometric indices in non\u2010alcoholic fatty liver patients: An umbrella meta\u2010analysis"],"prefix":"10.1002","volume":"38","author":[{"given":"Roghayeh","family":"Molani\u2010Gol","sequence":"first","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Dehghani","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-1253","authenticated-orcid":false,"given":"Maryam","family":"Rafraf","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6328"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.01.016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.06.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00649"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666161010115235"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200303114934"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.11.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24097"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6542"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31820-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.09.015"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1074"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091153"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-01916-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1690453"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf204496f"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1414"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083397"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-11-RG-105"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_10_25_1","first-page":"87","article-title":"Effect of medicinal plants and natural products on liver enzymes in non\u2010alcoholic fatty liver patients in Iran: A systematic review and meta\u2010analysis. 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