{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:47:13Z","timestamp":1766159233755,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current research is designed to investigate the effect of propolis supplementation on the clinical manifestations in women suffering from uncomplicated cystitis. In this randomized double\u2010blind, placebo\u2010controlled trial, 120 women with uncomplicated cystitis were selected and randomly assigned into two groups to receive two 500\u2009mg capsules of propolis or placebo daily for 7\u2009days along with ciprofloxacin (250\u2009mg). Clinical symptoms including hematuria, urinary frequency, dysuria, suprapubic pain, and urgency, as well as bacteriuria, were assessed before and after the intervention. After supplementation, participants in the intervention group had significantly fewer days of urinary frequency (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), dysuria (<jats:italic>p<\/jats:italic>\u2009=\u20090.005), and urgency (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). However, there was no significant difference between the two groups regarding hematuria and suprapubic pain (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Furthermore, the severity of bacteriuria decreased significantly in both groups. In conclusion, it seems that propolis supplementation in women with uncomplicated cystitis could improve urinary frequency, dysuria, and urgency. However, further clinical trials should be conducted to fully understand the effects of propolis in women suffering from uncomplicated cystitis.<\/jats:p>","DOI":"10.1002\/ptr.8053","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:23:51Z","timestamp":1698755031000},"page":"520-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Propolis as an adjunctive therapy for treatment of uncomplicated cystitis in women: A randomized double\u2010blind placebo\u2010controlled trial"],"prefix":"10.1002","volume":"38","author":[{"given":"Mahdi","family":"Shekari","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Qom University of Medical Sciences  Qom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-6579","authenticated-orcid":false,"given":"Amir","family":"Hadi","sequence":"additional","affiliation":[{"name":"Halal Research Center of IRI, Food and Drug Administration Ministry of Health and Medical Education  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9861-9407","authenticated-orcid":false,"given":"Hamid Mahmood Abdullah","family":"Daabo","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Duhok Technical Institute Duhok Polytechnic University  Duhok Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra Haj","family":"Allahyari","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Nursing and Midwifery Qom University of Medical Sciences  Qom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1129-6930","authenticated-orcid":false,"given":"Ahmed","family":"Hjazi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences Prince Sattam bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-5972","authenticated-orcid":false,"given":"Nahid","family":"Rafie","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Qom University of Medical Sciences  Qom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/UA.UA_104_19"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.9734\/ARRB\/2015\/12676"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2021.035"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200503000-00007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-007-7083-y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5114\/pm.2021.105382"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-020-00086-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(91)90135-Z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.190"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg028"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6356"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-522"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01509"},{"key":"e_1_2_11_15_1","unstructured":"Mahdavi A. 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