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Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of \u03b2\u2010sitosterol and its potential applications is essential for scholarly pursuits and utilization purposes. \u03b2\u2010sitosterol shares similar chemical characteristics with cholesterol and exhibits several pharmacological activities without major toxicity. This study aims to bridge the gap between phytochemistry and current pharmacological evidence of \u03b2\u2010sitosterol, focusing on its anticancer activity and other biomedical properties. The goal is to provide a comprehensive understanding of \u03b2\u2010sitosterol's potential for future translational approaches. A thorough examination of the literature was conducted to gather relevant information on the biological properties of \u03b2\u2010sitosterol, particularly its anticancer therapeutic potential. Various databases were searched, including PubMed\/MedLine, Scopus, Google Scholar, and Web of Science using appropriate keywords. Studies investigating the effects of \u03b2\u2010sitosterol on different types of cancer were analyzed, focusing on mechanisms of action, pharmacological screening, and chemosensitizing properties. Modern pharmacological screening studies have revealed the potential anticancer therapeutic properties of \u03b2\u2010sitosterol against various types of cancer, including leukemia, lung, stomach, breast, colon, ovarian, and prostate cancer. \u03b2\u2010sitosterol has demonstrated chemosensitizing effects on cancer cells, interfering with multiple cell signaling pathways involved in proliferation, cell cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, and inflammation. Structural derivatives of \u03b2\u2010sitosterol have also shown anti\u2010cancer effects. However, research in the field of drug delivery and the detailed mode of action of \u03b2\u2010sitosterol\u2010mediated anticancer activities remains limited. \u03b2\u2010sitosterol, as a non\u2010toxic compound with significant pharmacological potential, exhibits promising anticancer effects against various cancer types. Despite being relatively less potent than conventional cancer chemotherapeutics, \u03b2\u2010sitosterol holds potential as a safe and effective nutraceutical against cancer. Further comprehensive studies are recommended to explore the biological properties of \u03b2\u2010sitosterol, including its mode of action, and develop novel formulations for its potential use in cancer treatment. This review provides a foundation for future investigations and highlights the need for further research on \u03b2\u2010sitosterol as a potent superfood in combating cancer.<\/jats:p>","DOI":"10.1002\/ptr.8061","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T06:16:40Z","timestamp":1699251400000},"page":"592-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Anticancer activity and other biomedical properties of \u03b2\u2010sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-7258","authenticated-orcid":false,"given":"Sudeshna","family":"Nandi","sequence":"first","affiliation":[{"name":"Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany University of Calcutta  Kolkata 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