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This lipophilic biomolecule displays antibacterial, pro\u2010apoptotic, antiproliferative, and anti\u2010inflammatory activities. In addition, in vitro and in vivo data showed that hyperforin is a promising molecule with potential applications in neurology and psychiatry. For instance, hyperforin possesses antidepressant properties, impairs the uptake of neurotransmitters, and stimulates the brain derived neurotrophic factor (BDNF)\/TrkB neurotrophic signaling pathway, the adult hippocampal neurogenesis, and the brain homeostasis of zinc. In fact, hyperforin is a multi\u2010target biomolecule with a complex neuropharmacological profile. However, one prominent pharmacological feature of hyperforin is its ability to influence the homeostasis of cations such as Ca<jats:sup>2+<\/jats:sup>, Na<jats:sup>+<\/jats:sup>, Zn<jats:sup>2+<\/jats:sup>, and H<jats:sup>+<\/jats:sup>. So far, the pathophysiological relevance of these actions is currently unknown. The main objective of the present work is to provide an overview of the cellular neurobiology of hyperforin, with a special focus on its effects on neuronal membranes and the movement of cations.<\/jats:p>","DOI":"10.1002\/ptr.8063","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T02:29:26Z","timestamp":1700015366000},"page":"636-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cellular neurobiology of hyperforin"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-7727","authenticated-orcid":false,"given":"Alexandre","family":"Bouron","sequence":"first","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, CNRS, CEA, Inserm UA13 BGE  Grenoble 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