{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:04:57Z","timestamp":1785546297176,"version":"3.56.0"},"reference-count":98,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSPD2024R744"],"award-info":[{"award-number":["RSPD2024R744"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Quercetin is the most common polyphenolic flavonoid present in fruits and vegetables demonstrating versatile health\u2010promoting effects. This study aimed to examine the effects of quercetin (QR) and sclareol (SCL) on the thiopental sodium (TS)\u2010induced sleeping and forced swimming test (FST) mouse models. SCL (1, 5, and 10\u2009mg\/kg, <jats:italic>p.o<\/jats:italic>.) or QR (50\u2009mg\/kg, p.o.) and\/or diazepam (DZP) (3\u2009mg\/kg, i.p.) were employed. After 30\u2009min of TS induction, individual or combined effects on the animals were checked. In the FST test, the animals were subjected to forced swimming after 30\u2009min of administration of the test and\/or controls for 5\u2009min. In this case, immobility time was measured. In silico studies were conducted to evaluate the involvement of GABA receptors. SCL (5 and 10\u2009mg\/kg) significantly increased the latency and decreased sleeping time compared to the control in the TS\u2010induced sleeping time study. DZP (3\u2009mg\/kg) showed a sedative\u2010like effect in animals in both sleeping and FST studies. QR (50\u2009mg\/kg) exhibited a similar pattern of activity as SCL. However, its effects were more prominent than those of SCL groups. SCL (10\u2009mg\/kg) altered the DZP\u20103\u2010mediated effects. SCL\u201010 co\u2010treated with QR\u201050 significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) increased the latency and decreased sleep time and immobility time, suggesting possible synergistic antidepressant\u2010like effects. In silico studies revealed that SCL and QR demonstrated better binding affinities with GABAA receptor, especially \u03b1<jats:sub>2<\/jats:sub>, \u03b1<jats:sub>3<\/jats:sub>, and \u03b1<jats:sub>5<\/jats:sub> subunits. Both compounds also exhibited good ADMET and drug\u2010like properties. In animal studies, the both compounds worked synergistically to provide antidepressant\u2010like effects in a slightly different fashion. As a conclusion, the combined administration of SCL and QR may be used in upcoming neurological clinical trials, according to in vivo and in silico findings. However, additional investigation is necessary to verify this behavior and clarify the potential mechanism of action.<\/jats:p>","DOI":"10.1002\/ptr.8139","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T06:40:31Z","timestamp":1709102431000},"page":"2198-2214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Quercetin increases the antidepressant\u2010like effects of sclareol and antagonizes diazepam in thiopental sodium\u2010induced sleeping mice: A possible <scp>GABAergic<\/scp> transmission intervention"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-2944","authenticated-orcid":false,"given":"Mehedi Hasan","family":"Bappi","sequence":"first","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Nayem","family":"Mia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddique Akber","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan Aamer","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Drug Science and Technology University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Al Shamsh","family":"Prottay","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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