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This review discussed and critically analyzed the potent anti\u2010inflammatory and immunosuppressive effects of several phytochemicals and their underlying mechanisms in association with RA in experimental studies, including preliminary clinical studies of some of them. A wide range of phytochemicals including phenols, flavonoids, chalcones, xanthones, terpenoids, alkaloids, and glycosides have shown significant immunosuppressive and anti\u2010inflammatory activities in experimental RA models and a few have undergone clinical trials for their efficacy and safety in reducing RA symptoms and improve patient outcomes. These phytochemicals have potential as safer alternatives to the existing drugs in the management of RA, which possess a wide range of serious side effects. Sufficient preclinical studies on safety and efficacy of these phytochemicals must be performed prior to proper clinical studies. Further studies are needed to address the barriers that have so far limited their human use before the therapeutic potential of these plant\u2010based chemicals as anti\u2010arthritic agents in the treatment of RA is fully realized.<\/jats:p>","DOI":"10.1002\/ptr.8147","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T02:10:58Z","timestamp":1712801458000},"page":"2931-2961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Mechanistic insights into anti\u2010inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0211-3781","authenticated-orcid":false,"family":"Yuandani","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical\/Community Pharmacy, Faculty of Pharmacy Universitas Sumatera Utara  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