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This review delves into the roles of key natural phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis and their underlying mechanisms. Emphasizing the significance of amino acid, lipid, and iron metabolism, the study elucidates the diverse pathways through which these phenols regulate ferroptosis. Notably, curcumin, a well\u2010known polyphenol, exhibits multifaceted interactions with cellular components involved in ferroptosis regulation, providing a distinctive therapeutic avenue. Stilbenes, another phenolic class, demonstrate promising potential in influencing lipid metabolism and iron\u2010dependent processes, contributing to ferroptotic cell death. Understanding the intricate interplay between these natural phenols and ferroptosis not only illuminates complex cellular regulatory networks but also unveils potential avenues for novel cancer therapies. Exploring these compounds as inducers of ferroptosis presents a promising strategy for targeted cancer treatment, capitalizing on the delicate balance between cellular metabolism and regulated cell death mechanisms. This article synthesizes current knowledge, aiming to stimulate further research into the therapeutic potential of natural phenols in the context of ferroptosis\u2010mediated cancer therapy.<\/jats:p>","DOI":"10.1002\/ptr.8149","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T12:36:44Z","timestamp":1708691804000},"page":"2041-2076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Yiping","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Life Sciences Fudan University  Shanghai China"},{"name":"Wanchuanhui (Shanghai) Medical Technology Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-9248","authenticated-orcid":false,"given":"Jun","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Life Sciences Fudan University  Shanghai China"},{"name":"Wanchuanhui (Shanghai) Medical Technology Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020221"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.908487"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111642"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S233567"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195997"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25143146"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24637"},{"key":"e_1_2_15_9_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/5299218","article-title":"Quercetin promotes TFEB nuclear translocation and activates lysosomal degradation of ferritin to induce ferroptosis in breast cancer cells","volume":"2022","author":"An S.","year":"2022","journal-title":"Computational Intelligence and Neuroscience"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-016-0217-2"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02677-w"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112576"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11213323"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7386"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061505"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3044024"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05738-8"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmu132"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261370"},{"key":"e_1_2_15_20_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/4607966","article-title":"Ferulic acid mitigates growth and invasion of esophageal squamous cell carcinoma through inducing ferroptotic cell death","volume":"2022","author":"Cao Y.","year":"2022","journal-title":"Disease Markers"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08555-w"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11030554"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2022.105325"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6896790"},{"key":"e_1_2_15_25_1","doi-asserted-by":"crossref","unstructured":"Chen J.\u2010W. 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