{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:53:13Z","timestamp":1793379193202,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["73057"],"award-info":[{"award-number":["73057"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases. Several meta\u2010analyses have shown that curcumin could improve the function of the knee and alleviate pain in OA, while some meta\u2010analyses demonstrate controversial results. Hence, we assessed curcumin's effects on knee OA in an umbrella meta\u2010analysis. PubMed, Scopus, Embase, and Web of Science databases were employed to find English\u2010language meta\u2010analyses of randomized controlled trials investigating the effect of curcumin supplementation on OA outcomes up to September 2023. The visual analog scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain, function, and stiffness scales were analyzed. Effect sizes and 95% confidence intervals were utilized to obtain the overall effect size. A random\u2010effects model was applied to perform the meta\u2010analysis. Heterogeneity was determined by <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistics and the Cochrane Q\u2010test. The pooled effect of the 11 included meta\u2010analyses showed that curcumin could significantly decrease the VAS score (weighted mean difference [WMD] and standardized mean difference [SMD]), WOMAC\u2010total (SMD and WMD), WOMAC\u2010Function (SMD and WMD), WOMAC\u2010Pain (SMD), and WOMAC\u2010Stiffness scores (SMD) (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001, \u22640.001, \u22640.001, 0.007, \u22640.001, 0.002, \u22640.001, \u22640.001, respectively). The results strongly support curcuminoid supplementation in relieving pain, improving joint mobility and stiffness, and shortening medication usage of OA patients.<\/jats:p>","DOI":"10.1002\/ptr.8153","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T05:53:35Z","timestamp":1712296415000},"page":"2875-2891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The efficacy of curcumin in relieving osteoarthritis: A meta\u2010analysis of meta\u2010analyses"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-6547","authenticated-orcid":false,"given":"Mohammad Vesal","family":"Bideshki","sequence":"first","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Department of Biochemistry and Diet Therapy, School of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Jourabchi\u2010Ghadim","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Department of Biochemistry and Diet Therapy, School of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Radkhah","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-5008","authenticated-orcid":false,"given":"Mehrdad","family":"Behzadi","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Nutrition and Food Sciences Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Asemani","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Department of Biochemistry and Diet Therapy, School of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parmida","family":"Jamilian","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Bioengineering Keele University  Staffordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-4178","authenticated-orcid":false,"given":"Meysam","family":"Zarezadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Nutrition Research Center, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"19","article-title":"Efficacy of curcumin on inflammatory pain across different disorders: A systematic review and meta\u2010analysis of randomized controlled trials","volume":"19","author":"Alkarbi K.","year":"2021","journal-title":"World Family Medicine Journal\/Middle East Journal of Family Medicine."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.20f13681"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106607"},{"issue":"3","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.semarthrit.2018.03.001","article-title":"Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta\u2010analysis","volume":"48","author":"Bannuru R. 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