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To date, the clinical management of body weight gain is an unmet medical need, as there are few approved anti\u2010obesity drugs and most require an extensive monitoring and vigilance due to risk of adverse effects and poor patient adherence\/persistence. Growing evidence has shown that the gasotransmitter hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) and, therefore, H<jats:sub>2<\/jats:sub>S\u2010donors could have a central role in the prevention and treatment of overweight\/obesity. The main natural sources of H<jats:sub>2<\/jats:sub>S\u2010donors are plants from the <jats:italic>Alliaceae<\/jats:italic> (garlic and onion), <jats:italic>Brassicaceae<\/jats:italic> (e.g., broccoli, cabbage, and wasabi), and <jats:italic>Moringaceae<\/jats:italic> botanical families. In particular, polysulfides and isothiocyanates, which slowly release H<jats:sub>2<\/jats:sub>S, derive from the hydrolysis of alliin from <jats:italic>Alliaceae<\/jats:italic> and glucosinolates from <jats:italic>Brassicaceae\/Moringaceae<\/jats:italic>, respectively. In this review, we describe the emerging role of endogenous H<jats:sub>2<\/jats:sub>S in regulating adipose tissue function and the potential efficacy of natural H<jats:sub>2<\/jats:sub>S\u2010donors in animal models of overweight\/obesity, with a final focus on the preliminary results from clinical trials. We conclude that organosulfur\u2010containing plants and their extracts could be used before or in combination with conventional anti\u2010obesity agents to improve treatment efficacy and reduce inflammation in obesogenic conditions. 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