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In this study, we aimed to evaluate the effects exerted by seven natural products (curcumin, silymarin, resveratrol, artichoke leaf extract, berberine, catechins, and naringenin) on patients with NAFLD. For this purpose, PubMed, Embase, Cochrane Library, and Web of Science, were searched for randomized controlled trials (RCTs) exclusively. The selected studies were evaluated for methodological quality via the Cochrane bias risk assessment tool, and data analysis software was used to analyze the data accordingly. The RCTs from the earliest available date until September 2022 were collected. This process resulted in 37 RCTs with a total sample size of 2509 patients being included. The results of the network meta\u2010analysis showed that artichoke leaf extract confers a relative advantage in reducing the aspartate aminotransferase (AST) levels (SUCRA: 99.1%), alanine aminotransferase (ALT) levels (SUCRA: 88.2%) and low\u2010density lipoprotein cholesterol (LDL\u2010C) levels (SUCRA: 88.9%). Naringenin conferred an advantage in reducing triglyceride (TG) levels (SUCRA: 97.3%), total cholesterol (TC) levels (SUCRA: 73.9%), and improving high\u2010density lipoprotein cholesterol (HDL\u2010C) levels (SUCRA: 74.9%). High\u2010density catechins significantly reduced body mass index (BMI) levels (SUCRA: 98.5%) compared with the placebo. The Ranking Plot of the Network indicated that artichoke leaf extract and naringenin performed better than the other natural products in facilitating patient recovery. Therefore, we propose that artichoke leaf extract and naringenin may exert a better therapeutic effect on NAFLD. This study may help guide clinicians and lead to further detailed studies.<\/jats:p>","DOI":"10.1002\/ptr.8182","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T02:53:15Z","timestamp":1718679195000},"page":"3801-3824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of different natural products in patients with non\u2010alcoholic fatty liver disease\u2014A network meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"38","author":[{"given":"Hongshuai","family":"Liu","sequence":"first","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine  Jinan People's Republic of 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