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This review provides a synopsis of\n                    <jats:italic>H. perforatum<\/jats:italic>\n                    L. phytoconstituents and their biological effects, highlighting its beneficial therapeutic properties for dermatological indications, as well as its antioxidant, antimicrobial, anti\u2010inflammatory, and anti\u2010angiogenic activity in various applications including wound healing and skin conditions such as eczema, sun burn and minor burns also spastic paralysis, stiff neck and mood disorders as anti\u2010depressant and nerve pains such as neuralgia. The data were collected from several databases as Web of Science PubMed, ScienceDirect, Scopus and Google Scholar using the terms: \u201c\n                    <jats:italic>H. perforatum<\/jats:italic>\n                    L.\u201d, \u201c\n                    <jats:italic>H. perforatum<\/jats:italic>\n                    L. \/phytochemistry,\u201d and \u201c\n                    <jats:italic>H. perforatum<\/jats:italic>\n                    extracts\/wound healing\u201d collected from 1994 to 2023. The findings suggest\n                    <jats:italic>H. perforatum<\/jats:italic>\n                    L. acts through various mechanisms and plays a role in each phase of the wound healing process, including re\u2010epithelialization, angiogenesis, wound contraction, and connective tissue regeneration.\n                    <jats:italic>H. perforatum<\/jats:italic>\n                    L. enhances collagen deposition, decreases inflammation, inhibits fibroblast migration, and promotes epithelialization by increasing the number of fibroblasts with polygonal shape and the number of collagen fibers within fibroblasts.\n                    <jats:italic>H. Perforatum L.<\/jats:italic>\n                    extracts modulate the immune response and reduce inflammation were found to accelerate the wound healing process via inhibition of inflammatory mediators' production like interleukin\u20106, tumor necrosis factor\u2010\u03b1, cyclooxygenase\u20102 gene expression, and inducible nitric oxide synthase. Thus,\n                    <jats:italic>H. perforatum<\/jats:italic>\n                    L. represents a potential remedy for a wide range of dermatological problems, owing to its constituents with beneficial therapeutic properties.\n                    <jats:italic>H. perforatum<\/jats:italic>\n                    L. could be utilized in the development of novel wound healing therapies.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8204","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T02:24:25Z","timestamp":1712802265000},"page":"3271-3295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The potential role of\n                    <scp>\n                      <i>Hypericum perforatum<\/i>\n                    <\/scp>\n                    in wound healing: A literature review on the phytochemicals, pharmacological approaches, and mechanistic perspectives"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-2487","authenticated-orcid":false,"given":"Bahareh","family":"Farasati Far","sequence":"first","affiliation":[{"name":"Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry Iran University of Science and Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazaleh","family":"Gouranmohit","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-7234","authenticated-orcid":false,"given":"Mohammad Reza","family":"Naimi\u2010jamal","sequence":"additional","affiliation":[{"name":"Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry Iran University of Science and Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfan","family":"Neysani","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4252-7647","authenticated-orcid":false,"given":"Heba A. S.","family":"El\u2010Nashar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-8288","authenticated-orcid":false,"given":"Mohamed","family":"El\u2010Shazly","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamyar","family":"Khoshnevisan","sequence":"additional","affiliation":[{"name":"Medical Nanotechnology and Tissue Engineering Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences  Tehran 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