{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:25:52Z","timestamp":1780392352254,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFE0100800"],"award-info":[{"award-number":["2023YFE0100800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The escalating incidence of nonalcoholic fatty liver disease (NAFLD) is closely associated with a high\u2010fat diet, leading to a decline in quality of life and significant health impairment. 7\u2010Hydroxyflavone (7\u2010HY) is a flavonoid known for its anti\u2010inflammatory, anticarcinogenic, and antioxidant effects. This study aims to assess the ameliorative effects of 7\u2010HY on NAFLD induced by a high\u2010fat diet and elucidate underlying mechanisms. Oleic acid\/palmitic acid\u2010induced HepG2 cells and C57BL\/6 mice on a high\u2010fat diet were utilized as in vitro and in vivo models. In animal experiments, 7\u2010HY was utilized as a dietary supplement. The 15\u2010week in vivo experiment monitored body weight, body fat percentage, glucose tolerance, insulin tolerance, and metabolic indexes. Commercial kits assessed triglyceride (TG) and total cholesterol levels in cells, liver tissue, and blood. Discovery Studio identified potential targets of 7\u2010HY, compared with NAFLD\u2010associated targets in the GeneCards database. Results indicated 7\u2010HY mitigated fat accumulation, hepatic steatosis, and oxidative stress induced by a high\u2010fat diet. Furthermore, 7\u2010HY showed potential efficacy in ameliorating abnormal glucose metabolism and promoting energy metabolism. Reverse target finding and molecular docking demonstrated a robust interaction between 7\u2010HY and serine\/threonine kinase 24 (STK24). Subsequent experimental results confirmed 7\u2010HY's ability to inhibit TG deposition in HepG2 cells through interaction with STK24. In conclusion, 7\u2010HY demonstrated the capacity to alleviate high\u2010fat diet\u2010induced NAFLD, presenting a novel strategy for the prevention and treatment of NAFLD.<\/jats:p>","DOI":"10.1002\/ptr.8207","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T05:54:12Z","timestamp":1714456452000},"page":"3444-3458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["7\u2010Hydroxyflavone improves nonalcoholic fatty liver disease by acting on <scp>STK24<\/scp>"],"prefix":"10.1002","volume":"38","author":[{"given":"Xinyi","family":"Qi","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, College of Animal Science and Technology Guangxi University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory 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